J Appl Microbiol. 2018 Aug 28; doi: 10.1111/jam.14092. Epub 2018 Aug 28.
Influence of phenothiazines, phenazines and phenoxazine on cation transport in Candida albicans.
Journal of applied microbiology
M Calahorra, N S Sánchez, A Peña
Affiliations
Affiliations
- Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, México.
PMID: 30153370
DOI: 10.1111/jam.14092
Abstract
AIMS: (i) To analyse the increase in calcium ion uptake caused by several cationic dyes on Candida albicans, (ii) to postulate a mechanism, (iii) to define the effects of Zn ions on the phenomenon, and (iv) to propose the use of the dyes or their derivatives against C. albicans.
METHODS AND RESULTS: Cells were grown in yeast peptone dextrose medium and starved. We measured the hydrophobic solvent/water partition coefficients and the dyes uptake by the cells and found no correlation with their hydrophobicity. Most of the dyes caused an increase in K
CONCLUSIONS: We propose a general mechanism for the stimulation of Ca
SIGNIFICANCE AND IMPACT OF THE STUDY: This study, in conjunction with previously published results, contribute to the basic research regarding ion transport in C. albicans and the role of zinc in this process. Besides, suggests the additional use of dyes, along with other antifungals agents, as combined therapy against candidiasis. Derived dyes from those used also might be possible therapeutic agents against this disease.
© 2018 The Society for Applied Microbiology.
Keywords:
Candida albicans
; calcium uptake; cation transport; dyes; potassium efflux
Publication Types
Grant support
