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Bandara K, Gunasekara C, Weerasekera M, et al. Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. Can J Infect Dis Med Microbiol. 2018;2018:9704532doi: 10.1155/2018/9704532.
Bandara, K., Gunasekara, C., Weerasekera, M., Marasinghe, C., Ranasinghe, N., & Fernando, N. (2018). Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 20189704532. https://doi.org/10.1155/2018/9704532
Bandara, Kanchana, et al. "Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?." The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale vol. 2018 (2018): 9704532. doi: https://doi.org/10.1155/2018/9704532
Bandara K, Gunasekara C, Weerasekera M, Marasinghe C, Ranasinghe N, Fernando N. Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?. Can J Infect Dis Med Microbiol. 2018 Jul 10;2018:9704532. doi: 10.1155/2018/9704532. eCollection 2018. PMID: 30123395; PMCID: PMC6079516.
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Can J Infect Dis Med Microbiol. 2018 Jul 10;2018:9704532. doi: 10.1155/2018/9704532. eCollection 2018.

Do the Th17 Cells Play a Role in the Pathogenesis of Leptospirosis?.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

Kanchana Bandara, Chinthika Gunasekara, Manjula Weerasekera, Chamil Marasinghe, Nilantha Ranasinghe, Neluka Fernando

Affiliations

  1. Department of Basic Sciences, Faculty of Allied Health Sciences, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka.
  2. Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  3. Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
  4. Out Patients Department, Base Hospital, Horana, Sri Lanka.

PMID: 30123395 PMCID: PMC6079516 DOI: 10.1155/2018/9704532

Abstract

OBJECTIVES: The aim of this study was to determine the level of five different pro- and anti-inflammatory cytokines to study the inflammatory response of leptospirosis.

MATERIALS AND METHODS: The serum cytokine levels of IL-10, IL-17A, IL-21, IL-23, and TNF-

RESULTS: Elevation of serum IL-10 and IL-17A levels and significant elevation of serum IL-21 (

CONCLUSION: Elevation of IL-17A together with the significant elevation of IL-21 and IL-23 suggests a possible involvement of Th17 cells in the immunopathogenesis of leptospirosis.

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