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Bello-Germino D, Chhin R, Tran T, et al. Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor. Case Rep Pediatr. 2018;2018:5938120doi: 10.1155/2018/5938120.
Bello-Germino, D., Chhin, R., Tran, T., & Vasylyeva, T. L. (2018). Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor. Case reports in pediatrics, 20185938120. https://doi.org/10.1155/2018/5938120
Bello-Germino, Daniella, et al. "Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor." Case reports in pediatrics vol. 2018 (2018): 5938120. doi: https://doi.org/10.1155/2018/5938120
Bello-Germino D, Chhin R, Tran T, Vasylyeva TL. Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor. Case Rep Pediatr. 2018 Jul 16;2018:5938120. doi: 10.1155/2018/5938120. eCollection 2018. PMID: 30123603; PMCID: PMC6079615.
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Case Rep Pediatr. 2018 Jul 16;2018:5938120. doi: 10.1155/2018/5938120. eCollection 2018.

Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor.

Case reports in pediatrics

Daniella Bello-Germino, Rasmey Chhin, Thu Tran, Tetyana L Vasylyeva

Affiliations

  1. Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

PMID: 30123603 PMCID: PMC6079615 DOI: 10.1155/2018/5938120

Abstract

Hypomelanosis of Ito is a neurocutaneous disorder characterized by skin manifestations in a characteristic pattern associated with musculoskeletal and central nervous system symptoms. Our patient was diagnosed with Wilms' tumor stage I at age two and was also found to have distinct streaked areas of skin hyper- and hypopigmentation suggestive of Hypomelanosis of Ito. We believe that our patient's clinical diagnoses of Hypomelanosis of Ito and Wilms' tumor are interlinked. The connecting factor is yet to be identified. Our patient does not have a deletion of 11p13 associated with a defect in WT1, the Wilms' tumor suppressor gene. As such, it is quite possible that what made her more susceptible to the development of Wilms' tumor was her Hypomelanosis of Ito, which is implicated in a number of other organ dysfunctions.

References

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