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Pelclova D, Zdimal V, Komarc M, et al. Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers. Nanomaterials (Basel). 2018;8(9)doi: 10.3390/nano8090731.
Pelclova, D., Zdimal, V., Komarc, M., Vlckova, S., Fenclova, Z., Ondracek, J., Schwarz, J., Kostejn, M., Kacer, P., Dvorackova, S., Popov, A., Klusackova, P., Zakharov, S., & Bello, D. (2018). Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers. Nanomaterials (Basel, Switzerland), 8(9), . https://doi.org/10.3390/nano8090731
Pelclova, Daniela, et al. "Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers." Nanomaterials (Basel, Switzerland) vol. 8,9 (2018). doi: https://doi.org/10.3390/nano8090731
Pelclova D, Zdimal V, Komarc M, Vlckova S, Fenclova Z, Ondracek J, Schwarz J, Kostejn M, Kacer P, Dvorackova S, Popov A, Klusackova P, Zakharov S, Bello D. Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers. Nanomaterials (Basel). 2018 Sep 16;8(9). doi: 10.3390/nano8090731. PMID: 30223600; PMCID: PMC6164906.
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Nanomaterials (Basel). 2018 Sep 16;8(9). doi: 10.3390/nano8090731.

Deep Airway Inflammation and Respiratory Disorders in Nanocomposite Workers.

Nanomaterials (Basel, Switzerland)

Daniela Pelclova, Vladimir Zdimal, Martin Komarc, Stepanka Vlckova, Zdenka Fenclova, Jakub Ondracek, Jaroslav Schwarz, Martin Kostejn, Petr Kacer, Stepanka Dvorackova, Alexey Popov, Pavlina Klusackova, Sergey Zakharov, Dhimiter Bello

Affiliations

  1. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague Na Bojišti 1, 128 00 Prague 2, Czech Republic. [email protected].
  2. Institute of Chemical Process Fundamentals of the CAS, Rozvojova 1/135, 165 02 Prague, Czech Republic. [email protected].
  3. Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Salmovska 1, 120 00 Prague, Czech Republic. [email protected].
  4. Faculty of Physical Education and Sport, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, José Marího 31, 162 52 Prague, Czech Republic. [email protected].
  5. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague Na Bojišti 1, 128 00 Prague 2, Czech Republic. [email protected].
  6. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague Na Bojišti 1, 128 00 Prague 2, Czech Republic. [email protected].
  7. Institute of Chemical Process Fundamentals of the CAS, Rozvojova 1/135, 165 02 Prague, Czech Republic. [email protected].
  8. Institute of Chemical Process Fundamentals of the CAS, Rozvojova 1/135, 165 02 Prague, Czech Republic. [email protected].
  9. Institute of Chemical Process Fundamentals of the CAS, Rozvojova 1/135, 165 02 Prague, Czech Republic. [email protected].
  10. Biocev, 1st Faculty of Medicine, Charles University, Prumyslova 595, 252 50 Vestec, Czech Republic. [email protected].
  11. Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, 461 17 Liberec, Czech Republic. [email protected].
  12. Department of Machining and Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, 461 17 Liberec, Czech Republic. [email protected].
  13. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague Na Bojišti 1, 128 00 Prague 2, Czech Republic. [email protected].
  14. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague Na Bojišti 1, 128 00 Prague 2, Czech Republic. [email protected].
  15. UMass, Lowell, Department of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, Lowell, MA 01854, USA. [email protected].

PMID: 30223600 PMCID: PMC6164906 DOI: 10.3390/nano8090731

Abstract

Thousands of researchers and workers worldwide are employed in nanocomposites manufacturing, yet little is known about their respiratory health. Aerosol exposures were characterized using real time and integrated instruments. Aerosol mass concentration ranged from 0.120 mg/m³ to 1.840 mg/m³ during nanocomposite machining processes; median particle number concentration ranged from 4.8 × 10⁴ to 5.4 × 10⁵ particles/cm³. The proportion of nanoparticles varied by process from 40 to 95%. Twenty employees, working in nanocomposite materials research were examined pre-shift and post-shift using spirometry and fractional exhaled nitric oxide (FeNO) in parallel with 21 controls. Pro-inflammatory leukotrienes (LT) type B4, C4, D4, and E4; tumor necrosis factor (TNF); interleukins; and anti-inflammatory lipoxins (LXA4 and LXB4) were analyzed in their exhaled breath condensate (EBC). Chronic bronchitis was present in 20% of researchers, but not in controls. A significant decrease in forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) was found in researchers post-shift (

Keywords: FeNO; exhaled breath condensate (EBC); inflammation; nanocomposites; nanoparticles; spirometry

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