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Poddar A, Aranha RR, K Muthukaliannan G, et al. Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis. BMJ Open. 2018;8(8):e020014doi: 10.1136/bmjopen-2017-020014.
Poddar, A., Aranha, R. R., K Muthukaliannan, G., Nachimuthu, R., & Jayaraj, R. (2018). Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis. BMJ open, 8(8), e020014. https://doi.org/10.1136/bmjopen-2017-020014
Poddar, Aayush, et al. "Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis." BMJ open vol. 8,8 (2018): e020014. doi: https://doi.org/10.1136/bmjopen-2017-020014
Poddar A, Aranha RR, K Muthukaliannan G, Nachimuthu R, Jayaraj R. Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis. BMJ Open. 2018 Aug 20;8(8):e020014. doi: 10.1136/bmjopen-2017-020014. PMID: 30127047; PMCID: PMC6104749.
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BMJ Open. 2018 Aug 20;8(8):e020014. doi: 10.1136/bmjopen-2017-020014.

Head and neck cancer risk factors in India: protocol for systematic review and meta-analysis.

BMJ open

Aayush Poddar, Ritchlynn Ronald Aranha, Gothandam K Muthukaliannan, Ramesh Nachimuthu, Rama Jayaraj

Affiliations

  1. School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
  2. College of Health and Human Sciences, Charles Darwin University, Darwin, Northern Territory, Australia.

PMID: 30127047 PMCID: PMC6104749 DOI: 10.1136/bmjopen-2017-020014

Abstract

INTRODUCTION: Demographic, behavioural and environmental factors have been associated with increased risk of head and neck cancer (HNC). We will review published reports and explore connections between risk factors and HNC incidence. This protocol aims to provide strategies for a systematic review and meta-analysis of HNC risk factor analysis in India. It also provides guidelines in order to visualise obtained HNC risk factor data in the form of a heat-map highlighting variations across gender, age and geographical location.

METHODS AND ANALYSIS: We will identify well-established HNC risk factors and perform a comprehensive systematic review and meta-analysis to quantify each risk factor's impact on HNC incidence. A systematic search will be performed to identify the studies and published reports of HNC risk factors in India. Meta-analysis will be conducted to estimate the proportional contribution of the most prevalent risk factor in HNC on a city-wide basis in Indian states and territories.

ETHICS AND DISSEMINATION: The review protocol draws on publicly available anonymised data without directly involving human participants and therefore requires neither formal human ethical review nor approval by a human research ethics committee. We published an outline of the protocol in the International Prospective Register of Systematic Reviews (PROSPERO) in 2017. The results will provide an updated analysis of HNC risk factor prevalence in India, and we will discuss the applicability of rehabilitation care. We plan to disseminate the findings of this systematic review through publication in a peer-reviewed journal and presentation at relevant conference proceedings.

PROSPERO REGISTRATION NUMBER: CRD42017077758.

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: alcohol; head and neck cancer; hpv; india; risk factors; tobacco

Conflict of interest statement

Competing interests: None declared.

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