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Eguchi H, Watanabe K, Kawakami N, et al. Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis. BMJ Open. 2018;8(8):e022612doi: 10.1136/bmjopen-2018-022612.
Eguchi, H., Watanabe, K., Kawakami, N., Ando, E., Arima, H., Asai, Y., Inoue, A., Inoue, R., Iwanaga, M., Imamura, K., Kobayashi, Y., Nishida, N., Otsuka, Y., Sakuraya, A., Tsuno, K., Shimazu, A., & Tsutsumi, A. (2018). Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis. BMJ open, 8(8), e022612. https://doi.org/10.1136/bmjopen-2018-022612
Eguchi, Hisashi, et al. "Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis." BMJ open vol. 8,8 (2018): e022612. doi: https://doi.org/10.1136/bmjopen-2018-022612
Eguchi H, Watanabe K, Kawakami N, Ando E, Arima H, Asai Y, Inoue A, Inoue R, Iwanaga M, Imamura K, Kobayashi Y, Nishida N, Otsuka Y, Sakuraya A, Tsuno K, Shimazu A, Tsutsumi A. Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis. BMJ Open. 2018 Aug 29;8(8):e022612. doi: 10.1136/bmjopen-2018-022612. PMID: 30158233; PMCID: PMC6119426.
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BMJ Open. 2018 Aug 29;8(8):e022612. doi: 10.1136/bmjopen-2018-022612.

Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis.

BMJ open

Hisashi Eguchi, Kazuhiro Watanabe, Norito Kawakami, Emiko Ando, Hideaki Arima, Yumi Asai, Akiomi Inoue, Reiko Inoue, Mai Iwanaga, Kotaro Imamura, Yuka Kobayashi, Norimitsu Nishida, Yasumasa Otsuka, Asuka Sakuraya, Kanami Tsuno, Akihito Shimazu, Akizumi Tsutsumi

Affiliations

  1. Department of Public Health, Kitasato University School of Medicine, Sagamihara, Japan.
  2. Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  3. The Japan Society for the Promotion of Science, Tokyo, Japan.
  4. Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
  5. Hitachi Automotive Systems, Ltd, Hitachinaka, Japan.
  6. Department of Psychiatric Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  7. Department of Psychiatric Nursing, Honda Motor Co., Ltd, Tokyo, UK.
  8. Kyoto Industrial Health Association, Kyoto, Japan.
  9. Faculty of Human Sciences, University of Tsukuba, Tokyo, Japan.
  10. Department of Hygiene, School of Medicine, School of Medicine, Wakayama Medical University, Wakayama, Japan.
  11. Center for Human and Sciences, College of Liberal Arts and Sciences, Kitasato University, Sagamihara, Japan.

PMID: 30158233 PMCID: PMC6119426 DOI: 10.1136/bmjopen-2018-022612

Abstract

INTRODUCTION: Chronic inflammation may be a mediator for the development of cardiovascular disease (CVD), metabolic diseases and psychotic and neurodegenerative disorders. Meta-analytic associations between work-related psychosocial factors and inflammatory markers have shown that work-related psychosocial factors could affect the flexibility and balance of the immune system. However, few systematic reviews or meta-analyses have investigated the association between work-related psychosocial factors and inflammatory markers. Based on prospective studies, the present investigation will conduct a comprehensive systematic review and meta-analysis of the association between work-related psychosocial factors and inflammatory markers.

METHODS AND ANALYSIS: The systematic review and meta-analysis will include published studies identified from electronic databases (PubMed, EMBASE, PsycINFO, PsycARTICLES, Web of Science and Japan Medical Abstracts Society) according to recommendations of the Meta-analysis of Observational Studies in Epidemiology guideline. Inclusion criteria are studies that: examined associations between work-related psychosocial factors and increased inflammatory markers; used longitudinal or prospective cohort designs; were conducted among workers; provided sufficient data for calculating ORs or relative risk with 95% CIs; were published as original articles in English or Japanese; and were published up to the end of 2017. Study selection, data extraction, quality assessment and statistical syntheses will be conducted by 14 investigators. Any inconsistencies or disagreements will be resolved through discussion. The quality of studies will be evaluated using the Risk of Bias Assessment Tool for Non-randomized Studies.

ETHICS AND DISSEMINATION: The investigation study will be based on published studies, so ethics approval is not required. The results of this study will be submitted for publication in a scientific peer-reviewed journal. The findings may be useful for assessing risk factors for increased inflammatory markers in the workplace and determining future approaches for preventing CVD, metabolic diseases and psychotic and neurodegenerative disorders.

PROSPERO REGISTRATION NUMBER: CRD42018081553.

© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords: cardiology; inflammation; mental health; occupational health; psychosocial factors at work; workplace

Conflict of interest statement

Competing interests: None declared.

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