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Huang Z, Liu Y, Qi G, et al. Role of Vitamin A in the Immune System. J Clin Med. 2018;7(9)doi: 10.3390/jcm7090258.
Huang, Z., Liu, Y., Qi, G., Brand, D., & Zheng, S. G. (2018). Role of Vitamin A in the Immune System. Journal of clinical medicine, 7(9), . https://doi.org/10.3390/jcm7090258
Huang, Zhiyi, et al. "Role of Vitamin A in the Immune System." Journal of clinical medicine vol. 7,9 (2018). doi: https://doi.org/10.3390/jcm7090258
Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018 Sep 06;7(9). doi: 10.3390/jcm7090258. PMID: 30200565; PMCID: PMC6162863.
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J Clin Med. 2018 Sep 06;7(9). doi: 10.3390/jcm7090258.

Role of Vitamin A in the Immune System.

Journal of clinical medicine

Zhiyi Huang, Yu Liu, Guangying Qi, David Brand, Song Guo Zheng

Affiliations

  1. Department of Pathology and Physiopathology, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  2. Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  3. Department of Pathology and Physiopathology, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  4. Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  5. Department of Pathology and Physiopathology, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  6. Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, Guangxi, China. [email protected].
  7. Research Service, VA Medical Center, Memphis, TN 38104, USA. [email protected].
  8. Department of Medicine, Division of Rheumatology, Milton S. Hershey Medical Center at Penn State University, Hershey, PA 17033, USA. [email protected].

PMID: 30200565 PMCID: PMC6162863 DOI: 10.3390/jcm7090258

Abstract

Vitamin A (VitA) is a micronutrient that is crucial for maintaining vision, promoting growth and development, and protecting epithelium and mucus integrity in the body. VitA is known as an anti-inflammation vitamin because of its critical role in enhancing immune function. VitA is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes. VitA has demonstrated a therapeutic effect in the treatment of various infectious diseases. To better understand the relationship between nutrition and the immune system, the authors review recent literature about VitA in immunity research and briefly introduce the clinical application of VitA in the treatment of several infectious diseases.

Keywords: immunology; infectious disease; vitamin A

References

  1. Annu Rev Nutr. 2001;21:167-92 - PubMed
  2. PLoS One. 2014 Aug 25;9(8):e105017 - PubMed
  3. J Exp Med. 2013 Jun 3;210(6):1117-24 - PubMed
  4. J Exp Med. 1925 Nov 30;42(6):753-77 - PubMed
  5. Science. 2007 Jul 13;317(5835):256-60 - PubMed
  6. Mucosal Immunol. 2011 Jan;4(1):66-82 - PubMed
  7. Int J Biomed Sci. 2008 Mar;4(1):52-7 - PubMed
  8. J Immunol. 2014 Apr 1;192(7):3336-44 - PubMed
  9. Immunity. 2010 Jan 29;32(1):129-40 - PubMed
  10. Zhongguo Dang Dai Er Ke Za Zhi. 2018 Feb;20(2):146-153 - PubMed
  11. J Immunol. 2009 Nov 15;183(10):6395-402 - PubMed
  12. J Nutr. 2014 Aug;144(8):1188-95 - PubMed
  13. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7293-7 - PubMed
  14. Gene. 2004 Mar 17;328:1-16 - PubMed
  15. Science. 2014 Jan 24;343(6169):432-7 - PubMed
  16. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G458-66 - PubMed
  17. Cancer Res. 2012 Oct 15;72(20):5230-9 - PubMed
  18. J Exp Med. 2007 Aug 6;204(8):1775-85 - PubMed
  19. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3432-40 - PubMed
  20. BMJ. 1994 Nov 26;309(6966):1404-7 - PubMed
  21. J Nutr Biochem. 2009 Jan;20(1):70-7 - PubMed
  22. Arch Ophthalmol. 1987 Sep;105(9):1224-8 - PubMed
  23. Immunity. 2011 Mar 25;34(3):435-47 - PubMed
  24. Nat Rev Immunol. 2010 Sep;10(9):664-74 - PubMed
  25. Am J Clin Nutr. 1988 Nov;48(5):1271-6 - PubMed
  26. Nat Rev Immunol. 2017 Jan;17(1):30-48 - PubMed
  27. J Immunol. 2010 Mar 1;184(5):2458-67 - PubMed
  28. J Nutr. 1997 Jul;127(7):1297-303 - PubMed
  29. Am J Clin Nutr. 2007 May;85(5):1335-43 - PubMed
  30. PLoS One. 2011;6(9):e24590 - PubMed
  31. Nat Immunol. 2012 Apr 29;13(6):587-95 - PubMed
  32. Immunity. 2008 May;28(5):639-50 - PubMed
  33. J Exp Med. 2008 Oct 27;205(11):2483-90 - PubMed
  34. J Exp Med. 2003 Feb 17;197(4):489-501 - PubMed
  35. Immunity. 2016 Mar 15;44(3):450-462 - PubMed
  36. J Nutr. 2000 May;130(5):1132-9 - PubMed
  37. Immunology. 2014 Jun;142(2):269-78 - PubMed
  38. J Exp Med. 2013 Sep 23;210(10):1961-76 - PubMed
  39. PLoS One. 2010 Dec 17;5(12):e15150 - PubMed
  40. Am J Dis Child. 1981 Jul;135(7):634-6 - PubMed
  41. Arch Pathol Lab Med. 1984 Oct;108(10):838-42 - PubMed
  42. J Leukoc Biol. 2014 Feb;95(2):275-83 - PubMed
  43. Eur Rev Med Pharmacol Sci. 2016 Dec;20(23):5009-5012 - PubMed
  44. Dev Biol. 2007 Mar 1;303(1):66-81 - PubMed
  45. J Immunol. 2012 Jul 15;189(2):1062-71 - PubMed
  46. J Nutr. 2008 Oct;138(10):1835-9 - PubMed
  47. Physiol Rev. 2000 Jul;80(3):1021-54 - PubMed
  48. J Biol Chem. 2004 Jan 2;279(1):77-85 - PubMed
  49. Blood. 2000 Jun 1;95(11):3349-56 - PubMed
  50. Z Gesamte Inn Med. 1981 Dec 1;36(23):897-902 - PubMed
  51. Eur J Immunol. 2013 Jun;43(6):1608-16 - PubMed
  52. Adv Nutr. 2017 Mar 15;8(2):197-212 - PubMed
  53. J Leukoc Biol. 2016 Jul;100(1):111-20 - PubMed
  54. Eur J Immunol. 2007 Sep;37(9):2396-9 - PubMed
  55. J Virol. 2011 Aug;85(16):8316-27 - PubMed
  56. Trends Immunol. 2006 May;27(5):235-43 - PubMed
  57. Infect Immun. 2015 Jul;83(7):2984-91 - PubMed
  58. J Immunol. 2016 May 1;196(9):3631-41 - PubMed
  59. Clin Infect Dis. 1994 Sep;19(3):489-99 - PubMed
  60. J Leukoc Biol. 2011 Dec;90(6):1191-7 - PubMed
  61. Clin Exp Immunol. 2013 Nov;174(2):302-17 - PubMed
  62. Cochrane Database Syst Rev. 2017 Sep 07;9:CD003648 - PubMed
  63. J Immunol. 2008 Aug 15;181(4):2277-84 - PubMed
  64. Am J Clin Nutr. 2007 Feb;85(2):333-45 - PubMed
  65. J Immunol. 2014 Mar 1;192(5):2280-2290 - PubMed
  66. Trends Immunol. 2011 Sep;32(9):412-9 - PubMed
  67. Nucl Recept Signal. 2009 May 08;7:e005 - PubMed
  68. Mucosal Immunol. 2008 Jan;1(1):38-48 - PubMed
  69. J Immunol. 2011 Jan 15;186(2):733-44 - PubMed
  70. Int J Tuberc Lung Dis. 2003 Aug;7(8):804-7 - PubMed
  71. J Biol Chem. 1998 Jan 23;273(4):2409-15 - PubMed
  72. J Nutr. 1991 Dec;121(12):1960-8 - PubMed
  73. Front Immunol. 2017 Nov 17;8:1560 - PubMed
  74. Arch Ophthalmol. 1990 Oct;108(10):1436-41 - PubMed
  75. BMJ. 2011 Aug 25;343:d5094 - PubMed
  76. J Microbiol Immunol Infect. 2008 Feb;41(1):17-25 - PubMed
  77. J Exp Med. 2007 Aug 6;204(8):1757-64 - PubMed
  78. World J Pediatr. 2009 Nov;5(4):275-81 - PubMed
  79. Nature. 2014 Apr 3;508(7494):123-7 - PubMed
  80. Ann N Y Acad Sci. 2010 Jan;1183:38-57 - PubMed
  81. Science. 2006 Nov 17;314(5802):1157-60 - PubMed
  82. Nature. 2015 Jan 15;517(7534):293-301 - PubMed
  83. Am J Respir Cell Mol Biol. 2017 Feb;56(2):233-241 - PubMed
  84. Int J Epidemiol. 2010 Apr;39 Suppl 1:i48-55 - PubMed
  85. Science. 2003 Feb 14;299(5609):1057-61 - PubMed
  86. EMBO J. 1991 Aug;10(8):2247-58 - PubMed
  87. AMA J Dis Child. 1958 Jan;95(1, Part 1):57-68 - PubMed
  88. Cell Mol Immunol. 2015 Sep;12(5):553-7 - PubMed
  89. Pediatrics. 1982 Jan;69(1):112-5 - PubMed
  90. J Exp Med. 1996 Dec 1;184(6):2271-8 - PubMed
  91. J Immunol. 2010 May 15;184(10):5519-26 - PubMed
  92. J Immunol. 2015 Aug 15;195(4):1368-71 - PubMed
  93. J Nutr. 1999 May;129(5):934-41 - PubMed
  94. Int J Tuberc Lung Dis. 2004 Sep;8(9):1130-3 - PubMed
  95. J Interferon Cytokine Res. 2015 Mar;35(3):200-12 - PubMed
  96. J Immunol. 2002 Oct 15;169(8):4183-9 - PubMed
  97. BMC Res Notes. 2017 Aug 23;10(1):421 - PubMed
  98. Clin Nutr. 2012 Aug;31(4):543-8 - PubMed
  99. Cell Immunol. 2010;265(2):156-63 - PubMed
  100. Biofactors. 2010 Nov-Dec;36(6):430-6 - PubMed
  101. Blood. 2011 Jan 13;117(2):530-41 - PubMed
  102. Cell Immunol. 2017 Dec;322:49-55 - PubMed
  103. J Trop Med Hyg. 1975 May;78(5):114-5 - PubMed
  104. Nature. 2011 Mar 10;471(7337):220-4 - PubMed
  105. Nutr J. 2013 Sep 23;12:131 - PubMed
  106. J Immunol. 2004 May 1;172(9):5213-21 - PubMed
  107. Cochrane Database Syst Rev. 2017 May 18;5:CD003650 - PubMed
  108. Br Med J. 1928 Oct 20;2(3537):691-6 - PubMed
  109. J Immunol. 2014 Apr 1;192(7):2953-8 - PubMed
  110. Proc Nutr Soc. 1999 May;58(2):289-93 - PubMed
  111. J Nutr. 2002 Dec;132(12):3809S-3813S - PubMed
  112. J Immunol. 2007 Feb 15;178(4):2018-27 - PubMed
  113. J Immunol. 2010 Sep 1;185(5):2675-9 - PubMed
  114. Eur J Immunol. 2008 Jan;38(1):147-55 - PubMed
  115. FASEB J. 1996 Jul;10(9):940-54 - PubMed
  116. J Exp Med. 2011 Aug 29;208(9):1767-75 - PubMed
  117. Vet Res Commun. 2014 Mar;38(1):59-62 - PubMed
  118. J Allergy Clin Immunol. 2018 Feb;141(2):650-658.e5 - PubMed
  119. Afr Health Sci. 2017 Jun;17(2):308-314 - PubMed
  120. Immunity. 2004 Oct;21(4):527-38 - PubMed
  121. Br J Nutr. 1972 Mar;27(2):299-304 - PubMed
  122. Nutr J. 2008 Jan 31;7:7 - PubMed
  123. Mucosal Immunol. 2016 Jan;9(1):183-93 - PubMed
  124. Nat Immunol. 2004 Jan;5(1):64-73 - PubMed
  125. Nat Immunol. 2002 Oct;3(10):944-50 - PubMed
  126. Cancer Res. 1993 May 15;53(10 Suppl):2287-99 - PubMed
  127. Clin Infect Dis. 2017 Sep 15;65(6):900-909 - PubMed
  128. Nutrition. 2010 Oct;26(10):958-62 - PubMed
  129. J Immunol. 2009 Jun 15;182(12):7459-72 - PubMed
  130. Pediatrics. 2014 Sep;134(3):e739-48 - PubMed
  131. Genes Dev. 2000 Jan 15;14(2):121-41 - PubMed
  132. J Immunol. 2013 Mar 1;190(5):2178-87 - PubMed
  133. Nutr Diet Suppl. 2017;2017(9):37-45 - PubMed
  134. Immunol Lett. 2017 Feb;182:24-29 - PubMed
  135. Virol J. 2013 Nov 14;10:337 - PubMed
  136. Nature. 2010 Apr 29;464(7293):1371-5 - PubMed
  137. J Exp Med. 2011 Jun 6;208(6):1127-33 - PubMed
  138. Clin Nutr. 2016 Feb;35(1):183-9 - PubMed
  139. J Immunol. 2010 Jun 15;184(12):6799-806 - PubMed
  140. Nutrition. 2011 Feb;27(2):227-32 - PubMed

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