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Knezl V, Sotníková R, Brnoliaková Z, et al. Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects. Interdiscip Toxicol. 2018;10(3):86-92doi: 10.1515/intox-2017-0014.
Knezl, V., Sotníková, R., Brnoliaková, Z., Stankovičová, T., Bauer, V., & Bezek, �. �. (2017). Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects. Interdisciplinary toxicology, 10(3), 86-92. https://doi.org/10.1515/intox-2017-0014
Knezl, Vladimír, et al. "Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects." Interdisciplinary toxicology vol. 10,3 (2017): 86-92. doi: https://doi.org/10.1515/intox-2017-0014
Knezl V, Sotníková R, Brnoliaková Z, Stankovičová T, Bauer V, Bezek Š. Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects. Interdiscip Toxicol. 2017 Nov;10(3):86-92. doi: 10.1515/intox-2017-0014. Epub 2018 Feb 14. PMID: 30174531; PMCID: PMC6107648.
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Interdiscip Toxicol. 2017 Nov;10(3):86-92. doi: 10.1515/intox-2017-0014. Epub 2018 Feb 14.

Monotherapy of experimental metabolic syndrome: II. Study of cardiovascular effects.

Interdisciplinary toxicology

Vladimír Knezl, Ružena Sotníková, Zuzana Brnoliaková, Tatiana Stankovičová, Viktor Bauer, Štefan Bezek

Affiliations

  1. Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská 9, 841 04 Bratislava, Slovakia.
  2. Department of Pharmacology and Toxicology, Comenius University in Bratislava, Faculty of Pharmacy, Odbojárov 10, 832 32 Bratislava 3, Slovakia.

PMID: 30174531 PMCID: PMC6107648 DOI: 10.1515/intox-2017-0014

Abstract

Metabolic syndrome belongs to the most important risk factors of cardiovascular diseases. The aim of this study was to investigate changes in cardiovascular system induced by high cholesterol and high fat diet (HCHF) in HTG rats and their influence by a pyridoindole antioxidant - SMe1EC2 (S). The effects of S were compared with those of atorvastatin (A). Male HTG rats were fed HCHF (1% cholesterol + 7.5% lard) for 4 weeks. S and A were administered p.o., 50 mg/kg b.w. Following experimental groups were used: Wistar rats (W), hypertriglyceridemic rats (HTG), HTG rats fed HCHF (CHOL), HTG+S (S-HTG), CHOL+S (S-CHOL), and CHOL+A (A-CHOL). Values of blood pressure (BP) and selected ECG parameters were monitored in conscious animals, functions of the isolated heart and aorta were analyzed

Keywords: SMe1EC2; atorvastatin; cardiovascular effects; high-fat and high-cholesterol diet; metabolic syndrome

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