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Pandurangan AK, Divya T, Kumar K, et al. Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World J Gastrointest Oncol. 2018;10(9):244-259doi: 10.4251/wjgo.v10.i9.244.
Pandurangan, A. K., Divya, T., Kumar, K., Dineshbabu, V., Velavan, B., & Sudhandiran, G. (2018). Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World journal of gastrointestinal oncology, 10(9), 244-259. https://doi.org/10.4251/wjgo.v10.i9.244
Pandurangan, Ashok Kumar, et al. "Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review." World journal of gastrointestinal oncology vol. 10,9 (2018): 244-259. doi: https://doi.org/10.4251/wjgo.v10.i9.244
Pandurangan AK, Divya T, Kumar K, Dineshbabu V, Velavan B, Sudhandiran G. Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World J Gastrointest Oncol. 2018 Sep 15;10(9):244-259. doi: 10.4251/wjgo.v10.i9.244. PMID: 30254720; PMCID: PMC6147765.
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World J Gastrointest Oncol. 2018 Sep 15;10(9):244-259. doi: 10.4251/wjgo.v10.i9.244.

Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review.

World journal of gastrointestinal oncology

Ashok Kumar Pandurangan, Thomas Divya, Kalaivani Kumar, Vadivel Dineshbabu, Bakthavatchalam Velavan, Ganapasam Sudhandiran

Affiliations

  1. Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, India.
  2. School of Life sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai 600048, India.
  3. Cell Biology Laboratory, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, India. [email protected].

PMID: 30254720 PMCID: PMC6147765 DOI: 10.4251/wjgo.v10.i9.244

Abstract

Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APC

Keywords: Apoptosis; Autophagy; Cell death; Colorectal cancer; Hippo signalling; Inflammation; Nuclear factor erythroid 2-related factor 2; Wnt signaling

Conflict of interest statement

Conflict-of-interest statement: We, the authors declare no conflict of interest.

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