Display options
Cite
Lattanzi R, Rief S, Schmidhammer H, et al. . Front Pharmacol. 2018;9:1002doi: 10.3389/fphar.2018.01002.
Lattanzi, R., Rief, S., Schmidhammer, H., Negri, L., & Spetea, M. (2018). . Frontiers in pharmacology, 91002. https://doi.org/10.3389/fphar.2018.01002
Lattanzi, Roberta, et al. "." Frontiers in pharmacology vol. 9 (2018): 1002. doi: https://doi.org/10.3389/fphar.2018.01002
Lattanzi R, Rief S, Schmidhammer H, Negri L, Spetea M. . Front Pharmacol. 2018 Aug 31;9:1002. doi: 10.3389/fphar.2018.01002. eCollection 2018. PMID: 30233377; PMCID: PMC6127270.
Copy Download .nbib Format: NLM
Share it on

Front Pharmacol. 2018 Aug 31;9:1002. doi: 10.3389/fphar.2018.01002. eCollection 2018.

[No title available]

Frontiers in pharmacology

Roberta Lattanzi, Silvia Rief, Helmut Schmidhammer, Lucia Negri, Mariana Spetea

Affiliations

  1. Department of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
  2. Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.

PMID: 30233377 PMCID: PMC6127270 DOI: 10.3389/fphar.2018.01002

Abstract

Pain, particularly chronic pain, is still an unsolved medical condition. Central goals in pain control are to provide analgesia of adequate efficacy and to reduce complications associated with the currently available drugs. Opioids are the mainstay for the treatment of moderate to severe pain. However, opioid pain medications also cause detrimental side effects, thus highlighting the need of innovative and safer analgesics. Opioids mediate their actions via the activation of opioid receptors, with the mu-opioid receptor as the primary target for analgesia, but also for side effects. One long-standing focus of drug discovery is the pursuit for new opioids exhibiting a favorable dissociation between analgesia and adverse effects. In this study, we describe the

Keywords: analgesia; binding affinity; constipation; morphinans; opioid agonist; opioid receptor; pain

References

  1. Neuropharmacology. 2018 Mar 15;131:238-255 - PubMed
  2. J Pain. 2008 Oct;9(10):883-91 - PubMed
  3. Drug Discov Today Technol. 2012;9(1):e23-e31 - PubMed
  4. Pharmacotherapy. 2002 Feb;22(2):240-50 - PubMed
  5. AAPS J. 2006 Mar 10;8(1):E118-25 - PubMed
  6. Br J Pharmacol. 2018 Jul;175(14):2857-2868 - PubMed
  7. Pharmacol Rev. 1987 Sep;39(3):197-249 - PubMed
  8. Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):168-180 - PubMed
  9. Nat Rev Drug Discov. 2017 Aug;16(8):545-564 - PubMed
  10. Behav Pharmacol. 2011 Sep;22(5-6):405-14 - PubMed
  11. Cell. 2017 Nov 16;171(5):1165-1175.e13 - PubMed
  12. Eur J Pharmacol. 2015 Sep 15;763(Pt B):206-13 - PubMed
  13. J Med Chem. 2004 Jun 3;47(12):3242-7 - PubMed
  14. Acta Physiol Hung. 2008 Mar;95(1):3-44 - PubMed
  15. J Pain. 2009 Jun;10(6):619-27 - PubMed
  16. ACS Chem Neurosci. 2017 Aug 16;8(8):1638-1640 - PubMed
  17. Curr Pharm Des. 2013;19(42):7435-50 - PubMed
  18. Pharmacol Rev. 2011 Dec;63(4):860-81 - PubMed
  19. Pain Ther. 2017 Dec;6(2):117-128 - PubMed
  20. Drug Discov Today. 2017 Nov;22(11):1719-1729 - PubMed
  21. J Med Chem. 2005 Jul 28;48(15):5052-5 - PubMed
  22. J Med Chem. 1984 Dec;27(12):1575-9 - PubMed
  23. Clin J Pain. 2010 Jan;26 Suppl 10:S10-5 - PubMed
  24. Life Sci. 2002 Mar 22;70(18):2177-85 - PubMed
  25. Pharmacol Rev. 2013 Sep 27;65(4):1257-317 - PubMed
  26. Top Curr Chem. 2011;299:93-119 - PubMed
  27. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5188-92 - PubMed
  28. Mini Rev Med Chem. 2011 Oct;11(12):1002-8 - PubMed
  29. J Clin Oncol. 2014 Jun 1;32(16):1655-61 - PubMed
  30. Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 - PubMed
  31. Pain Physician. 2008 Mar;11(2 Suppl):S105-20 - PubMed
  32. Am J Gastroenterol Suppl. 2014 Sep 10;2(1):17-21 - PubMed
  33. J Med Chem. 2017 Nov 22;60(22):9407-9412 - PubMed
  34. J Clin Pharm Ther. 2016 Aug;41(4):371-82 - PubMed
  35. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7203-7 - PubMed
  36. Curr Pharm Des. 2013;19(42):7415-34 - PubMed
  37. Psychopharmacology (Berl). 2010 Jun;210(2):109-19 - PubMed
  38. Br J Pharmacol. 2015 Jan;172(2):375-87 - PubMed
  39. Curr Med Res Opin. 2018 Apr;34(4):711-723 - PubMed
  40. Br J Pharmacol. 2018 Jul;175(14):2846-2856 - PubMed
  41. Neuron. 2016 Oct 19;92(2):294-297 - PubMed
  42. Brain Struct Funct. 2015 Mar;220(2):677-702 - PubMed
  43. Curr Med Chem. 2012;19(15):2442-57 - PubMed
  44. J Med Chem. 2017 Sep 14;60(17):7579-7590 - PubMed
  45. Front Psychiatry. 2018 Apr 23;9:119 - PubMed
  46. Br J Pharmacol. 2015 Jan;172(2):420-34 - PubMed
  47. Eur J Pharmacol. 1998 Jan 26;342(2-3):247-51 - PubMed
  48. Neuropharmacology. 2009;56 Suppl 1:205-12 - PubMed
  49. Anal Biochem. 1976 May 7;72:248-54 - PubMed
  50. Eur J Neurosci. 2008 May;27(10):2558-67 - PubMed
  51. Annu Rev Med. 2016;67:433-51 - PubMed
  52. PLoS One. 2014 Jun 11;9(6):e99231 - PubMed
  53. J Med Chem. 2003 Apr 24;46(9):1758-63 - PubMed
  54. Trends Pharmacol Sci. 2017 Nov;38(11):1016-1037 - PubMed
  55. Neurosci Lett. 2004 May 6;361(1-3):192-5 - PubMed
  56. Eur J Pharm Sci. 2010 Sep 11;41(1):125-35 - PubMed
  57. Pain Med. 2004 Mar;5 Suppl 1:S9-S27 - PubMed
  58. Neurosci Lett. 2018 Feb 18;: - PubMed
  59. J Med Chem. 2005 May 5;48(9):3372-8 - PubMed

Publication Types