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Martins GM, Teixeira MBCG, Silva MV, et al. Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone. Front Endocrinol (Lausanne). 2018;9:486doi: 10.3389/fendo.2018.00486.
Martins, G. M., Teixeira, M. B. C. G., Silva, M. V., Neofiti-Papi, B., Miranda-Rodrigues, M., Brum, P. C., & Gouveia, C. H. A. (2018). Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone. Frontiers in endocrinology, 9486. https://doi.org/10.3389/fendo.2018.00486
Martins, Gisele M, et al. "Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone." Frontiers in endocrinology vol. 9 (2018): 486. doi: https://doi.org/10.3389/fendo.2018.00486
Martins GM, Teixeira MBCG, Silva MV, Neofiti-Papi B, Miranda-Rodrigues M, Brum PC, Gouveia CHA. Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone. Front Endocrinol (Lausanne). 2018 Aug 28;9:486. doi: 10.3389/fendo.2018.00486. eCollection 2018. PMID: 30233491; PMCID: PMC6127616.
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Front Endocrinol (Lausanne). 2018 Aug 28;9:486. doi: 10.3389/fendo.2018.00486. eCollection 2018.

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone.

Frontiers in endocrinology

Gisele M Martins, Marília B C G Teixeira, Marcos V Silva, Bianca Neofiti-Papi, Manuela Miranda-Rodrigues, Patricia C Brum, Cecilia H A Gouveia

Affiliations

  1. Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  2. Department of Morphology, Federal University of Espírito Santo, Vitória, Brazil.
  3. Department of Morphology, Federal University of Sergipe, Aracaju, Brazil.
  4. School of Medicine, University of São Paulo, São Paulo, Brazil.
  5. University of Western Ontario, London, ON, Canada.
  6. School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.

PMID: 30233491 PMCID: PMC6127616 DOI: 10.3389/fendo.2018.00486

Abstract

Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid hormone (TH) interacts with the SNS to control several physiological processes, we raised the hypothesis that this interaction also controls bone remodeling. We have previously shown that mice with double-gene inactivation of α2A- and -adrenoceptors (α2A/2C-AR

Keywords: bone remodeling; cortical bone; sympathetic nervous system; thyroid hormone; thyrotoxicosis; trabecular bone; α2A-adrenoceptor

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