Display options
Cite
Svennebring A. The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica. 2015;46(7):659-663doi: 10.3109/00498254.2015.1104562.
Svennebring, A. (2016). The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 659-663. https://doi.org/10.3109/00498254.2015.1104562
Svennebring, Andreas. "The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein." Xenobiotica; the fate of foreign compounds in biological systems vol. 46,7 (2016): 659-663. doi: https://doi.org/10.3109/00498254.2015.1104562
Svennebring A. The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica. 2016 Jul;46(7):659-663. doi: 10.3109/00498254.2015.1104562. Epub 2015 Nov 02. PMID: 30179078.
Copy Download .nbib Format: NLM
Share it on

Xenobiotica. 2016 Jul;46(7):659-663. doi: 10.3109/00498254.2015.1104562. Epub 2015 Nov 02.

The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein.

Xenobiotica; the fate of foreign compounds in biological systems

Andreas Svennebring

Affiliations

  1. a Department of Pharmaceutical Biosciences , Division of Pharmaceutical Bioinformatics, Biomedical Centre, Uppsala University , Uppsala , Sweden.

PMID: 30179078 DOI: 10.3109/00498254.2015.1104562

Abstract

1. Øie-Tozer's model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins. 2. Concerns have been raised that the model is invalid for this purpose because it does not account for active drug transport, pH differences between fluids and extracellular tissue binding. 3. Here, it is demonstrated that these imperfections do not affect the outcome of the calculation.

Keywords: Disposition; distribution; dose fractions; drug concentration; free fraction; model imperfections; pharmacokinetics

Publication Types