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Krepuska M, Hubay M, Zima E, et al. Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs . Open Med Chem J. 2018;12:88-97doi: 10.2174/1874104501812010088.
Krepuska, M., Hubay, M., Zima, E., Kovacs, A., Kekesi, V., Kalasz, H., Szilagyi, B., Merkely, B., & Sotonyi, P. (2018). Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs . The open medicinal chemistry journal, 1288-97. https://doi.org/10.2174/1874104501812010088
Krepuska, Miklos, et al. "Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs ." The open medicinal chemistry journal vol. 12 (2018): 88-97. doi: https://doi.org/10.2174/1874104501812010088
Krepuska M, Hubay M, Zima E, Kovacs A, Kekesi V, Kalasz H, Szilagyi B, Merkely B, Sotonyi P. Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs . Open Med Chem J. 2018 Aug 31;12:88-97. doi: 10.2174/1874104501812010088. eCollection 2018. PMID: 30288180; PMCID: PMC6142673.
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Open Med Chem J. 2018 Aug 31;12:88-97. doi: 10.2174/1874104501812010088. eCollection 2018.

Hemodynamic Effects of the Light Stabilizer Tinuvin 770 in Dogs .

The open medicinal chemistry journal

Miklos Krepuska, Marta Hubay, Endre Zima, Aniko Kovacs, Violetta Kekesi, Huba Kalasz, Brigitta Szilagyi, Bela Merkely, Peter Sotonyi

Affiliations

  1. Heart and Vascular Center, Department of Vascular Surgery, Semmelweis University, Budapest, Hungary.
  2. Department of Forensic Pathology, Semmelweis University, Budapest, Hungary.
  3. Heart and Vascular Center, Department of Cardiology, Semmelweis University, Budapest, Hungary.
  4. Hungarian Institute for Forensic Sciences, Budapest, Hungary.
  5. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
  6. Department of Mathematical Geometry, Institute of Mathematics, University of Technology and Economics, Budapest, Hungary.

PMID: 30288180 PMCID: PMC6142673 DOI: 10.2174/1874104501812010088

Abstract

INTRODUCTION: Tinuvin 770 [bis(2,2,6,6-tetramethyl-4-piperidinyl) sebacate, Ciba-Geigy, Basel, Switzerland] is a UV light stabilizer that is a component of many plastic materials used world-wide in the medical and food industries. We report on the acute hemodynamic effects of Tinuvin 770 examined in dogs.

MATERIALS AND METHODS: Tinuvin 770 was dissolved in a mixture of saline and ethanol (1:1 v/v) and was administered to 12 intravenously narcotized and respirated dogs in increasing doses (T1-T7: 1, 3.3, 6.6, 10, 33.3, 66.6 and 100 mg, respectively). The doses were given as bolus injections over a three minute period, and the effects were recorded for 12 minutes. The vehicle was used as a control. Hemodynamic parameters (heart rate, blood pressure, end-diastolic pressure, dp/dt, cardiac output) and ECG were monitored continously.

RESULTS: At doses T1-T4, systolic and diastolic blood pressures, mean pressure and ventricular contractility were significantly decreased without significant changes in cardiac output, heart rate, or PQ interval. At doses T5 and T6, declines in blood pressure and myocardial contractility were observed. At doses T6 and T7, heart rate and PQ interval decreased substantially. Irreversible circulatory failure occured in one dog after administering dose T6 and in 8 dogs following dose T7.

CONCLUSION: Tinuvin 770 induces acute hemodynamic alterations. In lower doses, it causes peripheral vasodilatation, however at higher doses acute cardiac failure occured. Plastics containing Tinuvin 770 should be used with care in medical practice and the laboratory.

Keywords: Cardiotoxicity; Circulation; Hemodynamic parameters; L-type Ca2+ channel; Nicotinic acetylcholine receptor; Tinuvin 770; dp/dt

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