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Pietsch V, Deterding K, Attia D, et al. Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals. United European Gastroenterol J. 2018;6(8):1188-1198doi: 10.1177/2050640618786067.
Pietsch, V., Deterding, K., Attia, D., Ringe, K. I., Heidrich, B., Cornberg, M., Gebel, M., Manns, M. P., Wedemeyer, H., & Potthoff, A. (2018). Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals. United European gastroenterology journal, 6(8), 1188-1198. https://doi.org/10.1177/2050640618786067
Pietsch, Veronika, et al. "Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals." United European gastroenterology journal vol. 6,8 (2018): 1188-1198. doi: https://doi.org/10.1177/2050640618786067
Pietsch V, Deterding K, Attia D, Ringe KI, Heidrich B, Cornberg M, Gebel M, Manns MP, Wedemeyer H, Potthoff A. Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals. United European Gastroenterol J. 2018 Oct;6(8):1188-1198. doi: 10.1177/2050640618786067. Epub 2018 Jun 27. PMID: 30288281; PMCID: PMC6169054.
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United European Gastroenterol J. 2018 Oct;6(8):1188-1198. doi: 10.1177/2050640618786067. Epub 2018 Jun 27.

Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals.

United European gastroenterology journal

Veronika Pietsch, Katja Deterding, Dina Attia, Kristina Imeen Ringe, Benjamin Heidrich, Markus Cornberg, Michael Gebel, Michael Peter Manns, Heiner Wedemeyer, Andrej Potthoff

Affiliations

  1. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
  2. Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany.
  3. Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.

PMID: 30288281 PMCID: PMC6169054 DOI: 10.1177/2050640618786067

Abstract

BACKGROUND: The use of interferon-free direct-acting antiviral agents (DAAs) is associated with a rapid short-term decrease in liver stiffness in chronic hepatitis C-infected patients with sustained virologic response (SVR).

OBJECTIVE: The objective of this article is to evaluate long-term changes in liver elasticity in hepatitis C patients with SVR using transient elastography (TE), FIB-4 and APRI.

METHODS: A total of 143 patients were treated with DAAs and reached SVR. Patients received TE measurement (median (range)) at treatment start (baseline), follow-up week 24 (FU24) and follow-up week 96 (FU96). Laboratory data were examined at each date and FIB-4 and APRI were calculated.

RESULTS: Liver elasticity showed a significant decrease from baseline to FU24 (13.1 (3.1-75) kPa to 9.3 (2.9-69.1) kPa;

CONCLUSION: During long-term follow-up, the majority of patients with SVR had further improved liver stiffness values. Still, a significant proportion of patients may show long-term liver stiffness progression and thus continued TE follow-up is recommended.

Keywords: DAAs; HCV infection; Hepatitis C; SVR; direct-acting antivirals; liver elastography; liver stiffness; portal hypertension; sustained virological response; transient elastography

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