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Wilkinson AR, Carr SV, Klahn SL, et al. Hemophagocytic syndrome in a cat. JFMS Open Rep. 2018;4(2):2055116918795023doi: 10.1177/2055116918795023.
Wilkinson, A. R., Carr, S. V., Klahn, S. L., Dervisis, N. G., & Hanks, C. R. (2018). Hemophagocytic syndrome in a cat. JFMS open reports, 4(2), 2055116918795023. https://doi.org/10.1177/2055116918795023
Wilkinson, Ashley R, et al. "Hemophagocytic syndrome in a cat." JFMS open reports vol. 4,2 (2018): 2055116918795023. doi: https://doi.org/10.1177/2055116918795023
Wilkinson AR, Carr SV, Klahn SL, Dervisis NG, Hanks CR. Hemophagocytic syndrome in a cat. JFMS Open Rep. 2018 Aug 27;4(2):2055116918795023. doi: 10.1177/2055116918795023. eCollection 2018. PMID: 30181894; PMCID: PMC6113740.
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JFMS Open Rep. 2018 Aug 27;4(2):2055116918795023. doi: 10.1177/2055116918795023. eCollection 2018.

Hemophagocytic syndrome in a cat.

JFMS open reports

Ashley R Wilkinson, Susan V Carr, Shawna L Klahn, Nikolaos G Dervisis, Cory R Hanks

Affiliations

  1. Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.

PMID: 30181894 PMCID: PMC6113740 DOI: 10.1177/2055116918795023

Abstract

CASE SUMMARY: A 12-year-old male castrated domestic shorthair cat was evaluated for a 10 month history of weight loss. Thin body condition and a grade II/VI systolic parasternal heart murmur was noted during examination. Moderate-to-severe anemia and intermittent thrombocytopenia were identified on serial complete blood counts. Antibodies against feline immunodeficiency virus (FIV) were detected, but vaccination for FIV occurred previously. Echocardiography revealed biatrial and biventricular enlargement, left ventricular hypertrophy and pericardial effusion. Splenomegaly was present on abdominal ultrasound and cytological evaluation revealed macrophagic infiltration with erythrophagocytosis. Cytological evaluation of the bone marrow revealed similar findings. Histopathology of the spleen confirmed hemophagocytosis with no evidence of malignancy. A presumptive diagnosis of hemophagocytic syndrome was made. PCR testing for FIV on the splenic tissue was negative. The cat was treated with lomustine. Disease progression occurred approximately 6 months after diagnosis and the cat was euthanized.

RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is one of the few reports describing the diagnosis of hemophagocytic syndrome in a cat.

Keywords: Anemia; bone marrow; cardiomyopathy; hemophagocytic syndrome; immune-mediated diseases

Conflict of interest statement

Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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