Display options
Cite
Blau-Most M, Gepstein R, Rubowitz A. Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only. Am J Ophthalmol Case Rep. 2018;12:49-51doi: 10.1016/j.ajoc.2018.08.006.
Blau-Most, M., Gepstein, R., & Rubowitz, A. (2018). Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only. American journal of ophthalmology case reports, 1249-51. https://doi.org/10.1016/j.ajoc.2018.08.006
Blau-Most, Michal, et al. "Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only." American journal of ophthalmology case reports vol. 12 (2018): 49-51. doi: https://doi.org/10.1016/j.ajoc.2018.08.006
Blau-Most M, Gepstein R, Rubowitz A. Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only. Am J Ophthalmol Case Rep. 2018 Aug 29;12:49-51. doi: 10.1016/j.ajoc.2018.08.006. eCollection 2018 Dec. PMID: 30182070; PMCID: PMC6120346.
Copy Download .nbib Format: NLM
Share it on

Am J Ophthalmol Case Rep. 2018 Aug 29;12:49-51. doi: 10.1016/j.ajoc.2018.08.006. eCollection 2018 Dec.

Bilateral simultaneous central retinal vein occlusion in hyperviscosity retinopathy treated with systemic immunosuppressive therapy only.

American journal of ophthalmology case reports

Michal Blau-Most, Raz Gepstein, Alexander Rubowitz

Affiliations

  1. Department of Ophthalmology, Meir Medical Center, Kfar Sava, Israel.
  2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

PMID: 30182070 PMCID: PMC6120346 DOI: 10.1016/j.ajoc.2018.08.006

Abstract

PURPOSE: To describe the clinical presentation and imaging features of a patient presenting with bilateral central retinal vein occlusion (CRVO), who was subsequently diagnosed with hyperviscosity retinopathy due to B cell lymphoproliferative disease, and had a good response to systemic immunosuppressive therapy.

OBSERVATIONS: A clinical case report of an 87-year-old woman who presented with bilateral CRVO. Visual acuity, clinical examination, spectral domain optical coherence tomography (SD-OCT), color fundus photography and systemic evaluation were obtained. Ocular examination at presentation revealed bilateral CRVO, and OCT examination revealed significant central macular edema bilaterally. Six months after the diagnosis of hyperviscosity retinopathy and administration of systemic cyclophosphamide immunosuppressive therapy for B cell lymphoproliferative disease, most of the retinal hemorrhages resolved and partial resolution of the macular edema in the left eye was observed.

CONCLUSION AND IMPORTANCE: This case describes the association between bilateral simultaneous CRVO and hyperviscosity. Under unique circumstances our patient received systemic therapy alone, without plasmapheresis. Although only limited therapy was applied, she didn't have deterioration or recurrent events; she had a small improvement in her macular edema and a significant improvement in her systemic functional state as well as reduction in her monoclonal IGM level.

Keywords: Bilateral; CRVO; Hyperviscosity; Retinopathy; Waldenstrom's macroglobulinemia

References

  1. Clin Lymphoma Myeloma Leuk. 2013 Apr;13(2):238-40 - PubMed
  2. Br J Haematol. 2015 Aug;170(3):431-4 - PubMed
  3. Optometry. 2009 Jul;80(7):350-3 - PubMed
  4. Eye (Lond). 2008 Aug;22(8):1089-92 - PubMed
  5. Blood. 2015 Aug 6;126(6):721-32 - PubMed
  6. N Engl J Med. 2016 Jan 7;374(1):73 - PubMed

Publication Types