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Chowaniec M, Skoczyńska M, Sokolik R, et al. Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management. Reumatologia. 2018;56(4):249-254doi: 10.5114/reum.2018.77977.
Chowaniec, M., Skoczyńska, M., Sokolik, R., & Wiland, P. (2018). Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management. Reumatologia, 56(4), 249-254. https://doi.org/10.5114/reum.2018.77977
Chowaniec, Małgorzata, et al. "Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management." Reumatologia vol. 56,4 (2018): 249-254. doi: https://doi.org/10.5114/reum.2018.77977
Chowaniec M, Skoczyńska M, Sokolik R, Wiland P. Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management. Reumatologia. 2018;56(4):249-254. doi: 10.5114/reum.2018.77977. Epub 2018 Aug 31. PMID: 30237630; PMCID: PMC6142027.
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Reumatologia. 2018;56(4):249-254. doi: 10.5114/reum.2018.77977. Epub 2018 Aug 31.

Interstitial lung disease in systemic sclerosis: challenges in early diagnosis and management.

Reumatologia

Małgorzata Chowaniec, Marta Skoczyńska, Renata Sokolik, Piotr Wiland

Affiliations

  1. Department of Rheumatology and Internal Diseases, University Hospital in Wroc?aw, Poland.
  2. Department of Hygene, Wroc?aw Medical University, Poland.

PMID: 30237630 PMCID: PMC6142027 DOI: 10.5114/reum.2018.77977

Abstract

Interstitial lung disease (ILD) is a group of lung diseases characterized by thickening of the interstitium surrounding pulmonary alveolar walls. It is related to specific radiographic features in lung imaging and/or the presence of restrictive disorders in pulmonary function tests (PFTs). ILD is one of the leading causes of death in systemic sclerosis patients. Major risk factors of ILD associated with SSc (SSc-ILD) include male sex, diffuse type of cutaneous SSc and presence of anti-Scl-70 antibodies. SSc-ILD is challenging to diagnose at an early stage as the symptoms are non-specific. The greatest risk of its development is during the 4-5 years after the initial diagnosis of systemic sclerosis. Clinical vigilance at the time, including regular pulmonary function tests and/or high-resolution com-puted tomography (HRCT), is needed. The aim of this paper is to summarize the current knowledge on early diagnostic methods and progression risk factors for SSc-ILD.

Keywords: early diagnosis; interstitial lung disease; progression risk factors; systemic sclerosis

Conflict of interest statement

The authors declare no conflict of interest.

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