Display options
Cite
McKenzie AL, Hallberg SJ, Creighton BC, et al. A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR Diabetes. 2017;2(1):e5doi: 10.2196/diabetes.6981.
McKenzie, A. L., Hallberg, S. J., Creighton, B. C., Volk, B. M., Link, T. M., Abner, M. K., Glon, R. M., McCarter, J. P., Volek, J. S., & Phinney, S. D. (2017). A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR diabetes, 2(1), e5. https://doi.org/10.2196/diabetes.6981
McKenzie, Amy L, et al. "A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes." JMIR diabetes vol. 2,1 (2017): e5. doi: https://doi.org/10.2196/diabetes.6981
McKenzie AL, Hallberg SJ, Creighton BC, Volk BM, Link TM, Abner MK, Glon RM, McCarter JP, Volek JS, Phinney SD. A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes. JMIR Diabetes. 2017 Mar 07;2(1):e5. doi: 10.2196/diabetes.6981. PMID: 30291062; PMCID: PMC6238887.
Copy Download .nbib Format: NLM
Share it on

JMIR Diabetes. 2017 Mar 07;2(1):e5. doi: 10.2196/diabetes.6981.

A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes.

JMIR diabetes

Amy L McKenzie, Sarah J Hallberg, Brent C Creighton, Brittanie M Volk, Theresa M Link, Marcy K Abner, Roberta M Glon, James P McCarter, Jeff S Volek, Stephen D Phinney

Affiliations

  1. Virta Health, San Francisco, CA, United States.
  2. Indiana University Health Arnett, Medically Supervised Weight Loss, Lafayette, IN, United States.

PMID: 30291062 PMCID: PMC6238887 DOI: 10.2196/diabetes.6981

Abstract

BACKGROUND: Type 2 diabetes (T2D) is typically managed with a reduced fat diet plus glucose-lowering medications, the latter often promoting weight gain.

OBJECTIVE: We evaluated whether individuals with T2D could be taught by either on-site group or remote means to sustain adequate carbohydrate restriction to achieve nutritional ketosis as part of a comprehensive intervention, thereby improving glycemic control, decreasing medication use, and allowing clinically relevant weight loss.

METHODS: This study was a nonrandomized, parallel arm, outpatient intervention. Adults with T2D (N=262; mean age 54, SD 8, years; mean body mass index 41, SD 8, kg·m

RESULTS: Baseline HbA

CONCLUSIONS: These initial results indicate that an individualized program delivered and supported remotely that incorporates nutritional ketosis can be highly effective in improving glycemic control and weight loss in adults with T2D while significantly decreasing medication use.

©Amy L McKenzie, Sarah J Hallberg, Brent C Creighton, Brittanie M Volk, Theresa M Link, Marcy K Abner, Roberta M Glon, James P McCarter, Jeff S Volek, Stephen D Phinney. Originally published in JMIR Diabetes (http://diabetes.jmir.org), 07.03.2017.

Keywords: Hb A1c; ketosis; mobile health; type 2 diabetes; weight loss

References

  1. JAMA. 1999 Jun 2;281(21):2005-12 - PubMed
  2. Int J Obes Relat Metab Disord. 2000 Jul;24(7):906-14 - PubMed
  3. N Engl J Med. 2002 Oct 24;347(17):1342-9 - PubMed
  4. Diabetes. 1976 Jun;25(6):494-504 - PubMed
  5. N Engl J Med. 2004 Dec 23;351(26):2683-93 - PubMed
  6. Ann Intern Med. 2005 Mar 15;142(6):403-11 - PubMed
  7. Nutr Metab (Lond). 2005 Dec 01;2:34 - PubMed
  8. Mol Cell Biochem. 2007 Aug;302(1-2):249-56 - PubMed
  9. Lipids. 2008 Jan;43(1):65-77 - PubMed
  10. Obes Surg. 2008 Mar;18(3):288-93 - PubMed
  11. Nutr Metab (Lond). 2008 May 22;5:14 - PubMed
  12. Lipids. 2009 Apr;44(4):297-309 - PubMed
  13. N Engl J Med. 2009 Jan 8;360(2):129-39 - PubMed
  14. Nutr Metab (Lond). 2008 Dec 19;5:36 - PubMed
  15. JAMA. 2009 Apr 15;301(15):1588-90 - PubMed
  16. Obesity (Silver Spring). 2010 Sep;18(9):1733-8 - PubMed
  17. Lipids. 2010 Oct;45(10):947-62 - PubMed
  18. Science. 2013 Jan 11;339(6116):211-4 - PubMed
  19. Diabetes Care. 2014;37(3):634-43 - PubMed
  20. PLoS One. 2014 Apr 09;9(4):e91027 - PubMed
  21. Diabetes Res Clin Pract. 2014 Nov;106(2):173-81 - PubMed
  22. Diabetes Care. 2014 Dec;37(12):3188-95 - PubMed
  23. Pharmacoeconomics. 2015 Jul;33(7):707-22 - PubMed
  24. Nat Med. 2015 Mar;21(3):263-9 - PubMed
  25. Am J Clin Nutr. 2015 Oct;102(4):780-90 - PubMed
  26. Curr Diab Rep. 2015 Dec;15(12):109 - PubMed
  27. Clin Diabetes. 2016 Jan;34(1):3-21 - PubMed
  28. Diabetes Care. 2016 May;39(5):808-15 - PubMed
  29. J Med Internet Res. 2016 Apr 19;18(4):e86 - PubMed
  30. Obesity (Silver Spring). 2016 Nov;24(11):2269-2277 - PubMed
  31. Diabetes Care. 1988 Jul-Aug;11(7):567-73 - PubMed
  32. Am J Med. 1988 Jul;85(1):38-46 - PubMed
  33. J Clin Invest. 1972 Oct;51(10):2757-62 - PubMed
  34. J Clin Invest. 1980 Nov;66(5):1152-61 - PubMed
  35. Am J Med. 1994 Oct;97(4):354-62 - PubMed
  36. Diabetes Care. 1993 Jan;16(1):21-31 - PubMed
  37. Am J Clin Nutr. 1996 Jan;63(1):110-5 - PubMed
  38. Lancet. 1998 Sep 12;352(9131):837-53 - PubMed

Publication Types