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Rizk MZ, Abo-El-Matty DM, Aly HF, et al. Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity. Toxicol Rep. 2018;5:929-942doi: 10.1016/j.toxrep.2018.08.021.
Rizk, M. Z., Abo-El-Matty, D. M., Aly, H. F., Abd-Alla, H. I., Saleh, S. M., Younis, E. A., Elnahrawy, A. M., & Haroun, A. A. (2018). Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity. Toxicology reports, 5929-942. https://doi.org/10.1016/j.toxrep.2018.08.021
Rizk, M Z, et al. "Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity." Toxicology reports vol. 5 (2018): 929-942. doi: https://doi.org/10.1016/j.toxrep.2018.08.021
Rizk MZ, Abo-El-Matty DM, Aly HF, Abd-Alla HI, Saleh SM, Younis EA, Elnahrawy AM, Haroun AA. Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity. Toxicol Rep. 2018 Sep 09;5:929-942. doi: 10.1016/j.toxrep.2018.08.021. eCollection 2018. PMID: 30294554; PMCID: PMC6170219.
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Toxicol Rep. 2018 Sep 09;5:929-942. doi: 10.1016/j.toxrep.2018.08.021. eCollection 2018.

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity.

Toxicology reports

M Z Rizk, D M Abo-El-Matty, H F Aly, H I Abd-Alla, S M Saleh, E A Younis, A M Elnahrawy, A A Haroun

Affiliations

  1. Therapeutic Chemistry Department, National Research Centre, Dokki12622, Giza, Egypt.
  2. Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Ismalia, Egypt.
  3. Chemistry of Natural Compounds Department, National Research Centre, Dokki12622, Giza, Egypt.
  4. Department of Solid State Physics, National Research Centre, Dokki 12622,Giza, Egypt.
  5. Chemical Industries Res Division, National Research Centre, Dokki12622, Giza, Egypt.

PMID: 30294554 PMCID: PMC6170219 DOI: 10.1016/j.toxrep.2018.08.021

Abstract

The current research aims to demonstrate the therapeutic effect of sour orange albedo extract (SOAE) and two flavanones loaded-tetraethylorthosilicate (TEOS) using sol-gel technique, in adose100 mg/kg body weight taken orally or45 days against acrylamide (ACR)toxicity in rats. This was achieved through measuring the activities of specific biochemical parameters related to liver functions in tissue of ACR intoxicated rats as compared to normal one. Liver functions included alanine and aspartate aminotransferases, antioxidants and oxidative stress biomarkers; superoxide dismutase, catalase, glutathione and lipid peroxide (malondialdehyde, MDA). Moreover, histological examination of liver was performed to confirm the biochemical findings. The present results clearly indicated disturbances in all biochemical parameters, such as increase in the liver function enzyme activities and MDA level. Results of ATPase enzyme activities revealed significant decrease in ACR intoxicated rats and liver biomarker enzymes declared significant decrease. On the other hand, treatment of intoxicated rats with the previous different nano-particles natural product demonstrated improvement in all biochemical parameters under investigation.

Keywords: Flavanones, acrylamide; Histopathology; Liver biochemical parameters; Nanocomposites; Sour orange albedo

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