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Exp Ther Med. 2018 Sep;16(3):2132-2137. doi: 10.3892/etm.2018.6419. Epub 2018 Jul 06.

The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions.

Experimental and therapeutic medicine

Ayman G Mustafa, Mahmoud A Alfaqih, Othman Al-Shboul

Affiliations

  1. Department of Basic Medical Sciences, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
  2. Department of Anatomy, School of Medicine, Qatar University, Doha, Qatar.
  3. Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

PMID: 30186450 PMCID: PMC6122424 DOI: 10.3892/etm.2018.6419

Abstract

Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes damage in the intravascular compartment is not yet exactly understood. Using an

Keywords: lipid peroxidation; oxidative stress; phenelzine; reactive oxygen species; thiobarbituric acid reactive substances

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