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Oncol Lett. 2018 Oct;16(4):4656-4662. doi: 10.3892/ol.2018.9228. Epub 2018 Jul 27.

Comparison of spatial chromosomal organization between bone marrow and peripheral blood in acute myeloid leukemia.

Oncology letters

Xueli Tian, Yanfang Wang, Yu Liu, Jun Yin, Dieyan Chen, Xiaoyan Ke, Wanyun Ma

Affiliations

  1. State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, P.R. China.
  2. Department of Hematology, Peking University Third Hospital, Beijing 100191, P.R. China.
  3. Collaborative Innovation Centre of Quantum Matter, Beijing 100084, P.R. China.

PMID: 30214600 PMCID: PMC6126258 DOI: 10.3892/ol.2018.9228

Abstract

Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB) samples are as informative as bone marrow (BM) samples during follow-up monitoring. However, few studies have compared the spatial organization of leukemia-specific chromosomes between BM and PB. In the present study, paired BM and PB samples were extracted from 6 patients with acute myeloid leukaemia-M2 and compared using three-dimensional fluorescence

Keywords: acute myeloid leukemia; bone marrow; peripheral blood; spatial organization; three-dimensional fluorescence in situ hybridization

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