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Kawamura T, Muraoka I. Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants (Basel). 2018;7(9)doi: 10.3390/antiox7090119.
Kawamura, T., & Muraoka, I. (2018). Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants (Basel, Switzerland), 7(9), . https://doi.org/10.3390/antiox7090119
Kawamura, Takuji, and Muraoka, Isao. "Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint." Antioxidants (Basel, Switzerland) vol. 7,9 (2018). doi: https://doi.org/10.3390/antiox7090119
Kawamura T, Muraoka I. Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint. Antioxidants (Basel). 2018 Sep 05;7(9). doi: 10.3390/antiox7090119. PMID: 30189660; PMCID: PMC6162669.
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Antioxidants (Basel). 2018 Sep 05;7(9). doi: 10.3390/antiox7090119.

Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint.

Antioxidants (Basel, Switzerland)

Takuji Kawamura, Isao Muraoka

Affiliations

  1. Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. [email protected].
  2. Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan. [email protected].

PMID: 30189660 PMCID: PMC6162669 DOI: 10.3390/antiox7090119

Abstract

It is well established that the increase in reactive oxygen species (ROS) and free radicals production during exercise has both positive and negative physiological effects. Among them, the present review focuses on oxidative stress caused by acute exercise, mainly on evidence in healthy individuals. This review also summarizes findings on the determinants of exercise-induced oxidative stress and sources of free radical production. Moreover, we outline the effects of antioxidant supplementation on exercise-induced oxidative stress, which have been studied extensively. Finally, the following review briefly summarizes future tasks in the field of redox biology of exercise. In principle, this review covers findings for the whole body, and describes human trials and animal experiments separately.

Keywords: animal experiments; antioxidants; exercise performance; exercise-induced oxidative stress; free radicals; human trials; muscle damage; reactive oxygen species

References

  1. Eur J Appl Physiol. 2004 May;91(5-6):615-21 - PubMed
  2. IUBMB Life. 2000 Jun;49(6):539-44 - PubMed
  3. Int J Sport Nutr Exerc Metab. 2001 Dec;11(4):466-81 - PubMed
  4. Eur J Appl Physiol. 2003 May;89(3-4):393-400 - PubMed
  5. Free Radic Biol Med. 2008 Jan 15;44(2):142-52 - PubMed
  6. Eur J Nutr. 2016 Feb;55(1):45-53 - PubMed
  7. Respir Physiol. 1994 Feb;95(2):227-37 - PubMed
  8. Eur J Appl Physiol. 2003 Mar;89(1):14-20 - PubMed
  9. Med Sci Sports Exerc. 2003 Jul;35(7):1139-45 - PubMed
  10. Int J Sports Med. 2000 Jul;21(5):369-74 - PubMed
  11. Free Radic Biol Med. 2003 Jun 15;34(12):1575-88 - PubMed
  12. Nature. 1966 May 7;210(5036):588-91 - PubMed
  13. Int J Sports Med. 2001 Jan;22(1):68-75 - PubMed
  14. J Sci Med Sport. 2007 Dec;10(6):411-7 - PubMed
  15. J Appl Physiol (1985). 1999 Dec;87(6):2032-6 - PubMed
  16. J Gerontol. 1985 May;40(3):281-6 - PubMed
  17. Eur J Appl Physiol Occup Physiol. 1998 May;77(6):498-502 - PubMed
  18. Med Sci Sports Exerc. 2008 Mar;40(3):542-8 - PubMed
  19. J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):927-32 - PubMed
  20. Am J Physiol. 1997 Jan;272(1 Pt 2):R363-9 - PubMed
  21. Oxid Med Cell Longev. 2012;2012:707941 - PubMed
  22. Toxicology. 2003 Jul 15;189(1-2):41-54 - PubMed
  23. Am J Physiol. 1992 Nov;263(5 Pt 2):R992-5 - PubMed
  24. Philos Trans R Soc Lond B Biol Sci. 1985 Dec 17;311(1152):617-31 - PubMed
  25. Free Radic Res. 2005 Nov;39(11):1219-24 - PubMed
  26. Eur J Appl Physiol. 2002 Jul;87(3):272-7 - PubMed
  27. Am J Physiol. 1993 Jul;265(1 Pt 2):R166-72 - PubMed
  28. Can J Physiol Pharmacol. 1991 Feb;69(2):279-84 - PubMed
  29. Eur J Appl Physiol. 2002 Jun;87(2):141-4 - PubMed
  30. Free Radic Biol Med. 2018 Feb 1;115:288-297 - PubMed
  31. J Clin Invest. 1994 Dec;94(6):2468-74 - PubMed
  32. Am J Respir Crit Care Med. 1997 Nov;156(5):1567-71 - PubMed
  33. Med Sci Sports Exerc. 1998 Jan;30(1):67-72 - PubMed
  34. Arch Biochem Biophys. 2009 Oct 15;490(2):77-84 - PubMed
  35. Free Radic Biol Med. 1999 Apr;26(7-8):1059-63 - PubMed
  36. Sports Med. 2006;36(5):429-41 - PubMed
  37. Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1518-27 - PubMed
  38. J Strength Cond Res. 2009 Nov;23(8):2419-24 - PubMed
  39. Eur J Appl Physiol. 2011 Oct;111(10):2557-69 - PubMed
  40. Biochem Biophys Res Commun. 1982 Aug 31;107(4):1198-205 - PubMed
  41. Pflugers Arch. 1998 Feb;435(3):439-41 - PubMed
  42. Physiol Rev. 2008 Oct;88(4):1243-76 - PubMed
  43. Pain. 1992 Sep;50(3):317-21 - PubMed
  44. Free Radic Biol Med. 2008 Jan 15;44(2):126-31 - PubMed
  45. Arch Biochem Biophys. 2003 Aug 1;416(1):1-8 - PubMed
  46. J Appl Physiol (1985). 2004 Oct;97(4):1477-85 - PubMed
  47. Can J Physiol Pharmacol. 1992 Oct;70(10):1392-5 - PubMed
  48. Int J Sport Nutr Exerc Metab. 2010 Feb;20(1):2-14 - PubMed
  49. Free Radic Res. 2007 Feb;41(2):182-90 - PubMed
  50. Int J Biochem. 1989;21(8):835-8 - PubMed
  51. Sports Med. 1999 Mar;27(3):157-70 - PubMed
  52. Am J Physiol. 1994 Aug;267(2 Pt 2):R439-45 - PubMed
  53. J Physiol. 2016 Sep 15;594(18):5135-47 - PubMed
  54. Redox Biol. 2014 Feb 19;2:520-8 - PubMed
  55. Clin Sci (Lond). 1999 Jan;96(1):105-15 - PubMed
  56. J Appl Physiol (1985). 1999 Jul;87(1):465-70 - PubMed
  57. J Clin Invest. 1992 Dec;90(6):2502-7 - PubMed
  58. Biochem Biophys Res Commun. 2008 Feb 22;366(4):892-7 - PubMed
  59. Med Sci Sports Exerc. 2007 Jul;39(7):1080-9 - PubMed
  60. Acta Physiol Scand. 1994 Jun;151(2):149-58 - PubMed
  61. Res Sports Med. 2009 Jan-Mar;17(1):1-16 - PubMed
  62. J Sports Med Phys Fitness. 1997 Dec;37(4):235-9 - PubMed
  63. Mol Cell Biochem. 1999 Jun;196(1-2):31-42 - PubMed
  64. Med Sci Sports Exerc. 2009 Sep;41(9):1752-60 - PubMed
  65. Am J Physiol. 1993 Dec;265(6 Pt 2):H2094-8 - PubMed
  66. Eur J Appl Physiol. 2005 Dec;95(5-6):543-9 - PubMed
  67. Ciba Found Symp. 1983;101:56-69 - PubMed
  68. Muscle Nerve. 1989 Apr;12(4):332-6 - PubMed
  69. Int J Sport Nutr Exerc Metab. 2014 Dec;24(6):684-93 - PubMed
  70. Antioxid Redox Signal. 2013 Feb 20;18(6):603-21 - PubMed
  71. Int J Sports Med. 1992 Jul;13(5):412-6 - PubMed
  72. Free Radic Biol Med. 2001 Sep 15;31(6):745-53 - PubMed
  73. Mol Cell Biochem. 1992 Apr;111(1-2):109-15 - PubMed
  74. J Appl Physiol (1985). 2010 Aug;109(2):449-56 - PubMed
  75. J Appl Physiol (1985). 1992 Oct;73(4):1265-72 - PubMed
  76. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1071-7 - PubMed
  77. Eur J Appl Physiol. 2001 Jan-Feb;84(1-2):1-6 - PubMed
  78. Science. 1973 Dec 21;182(4118):1271-2 - PubMed
  79. Med Sci Sports Exerc. 2002 Mar;34(3):443-8 - PubMed
  80. Can J Appl Physiol. 2000 Aug;25(4):274-87 - PubMed
  81. Biochem J. 1973 Jul;134(3):707-16 - PubMed
  82. Appl Physiol Nutr Metab. 2013 May;38(5):558-65 - PubMed
  83. Eur J Appl Physiol. 2004 Jul;92(3):321-7 - PubMed
  84. Eur J Appl Physiol. 2016 Apr;116(4):791-804 - PubMed
  85. Arch Biochem Biophys. 1995 Feb 1;316(2):941-9 - PubMed
  86. Lipids Health Dis. 2004 Jun 22;3:14 - PubMed
  87. Am J Clin Nutr. 2008 Jan;87(1):142-9 - PubMed
  88. Eur J Appl Physiol. 2004 Jun;92(1-2):133-8 - PubMed
  89. J Physiol. 2006 Oct 1;576(Pt 1):279-88 - PubMed
  90. Free Radic Biol Med. 1990;8(1):9-13 - PubMed
  91. J Appl Physiol (1985). 1996 Apr;80(4):1331-5 - PubMed
  92. Am J Physiol. 1988 Dec;255(6 Pt 1):C874-7 - PubMed
  93. Biochem Biophys Res Commun. 2009 May 22;383(1):103-7 - PubMed
  94. Free Radic Res. 2016;50(11):1237-1244 - PubMed
  95. Int J Sport Nutr. 1997 Mar;7(1):1-9 - PubMed
  96. Can J Appl Physiol. 2003 Feb;28(1):79-92 - PubMed
  97. Med Sci Sports Exerc. 2006 Jun;38(6):1098-105 - PubMed
  98. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R345-53 - PubMed
  99. J Physiol. 2011 May 1;589(Pt 9):2129-38 - PubMed
  100. Med Sci Sports Exerc. 2004 Dec;36(12):2065-72 - PubMed
  101. Redox Biol. 2015;4:180-3 - PubMed
  102. Int J Sports Med. 2007 Jan;28(1):21-5 - PubMed
  103. J Physiol. 2016 Sep 15;594(18):5081-92 - PubMed
  104. Med Sci Sports Exerc. 1993 Oct;25(10):1135-40 - PubMed
  105. Eur J Appl Physiol Occup Physiol. 1996;72(3):189-94 - PubMed
  106. Am J Physiol. 1994 Feb;266(2 Pt 2):R375-80 - PubMed
  107. Biochim Biophys Acta. 1985 Nov 20;847(2):185-90 - PubMed
  108. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E779-84 - PubMed
  109. Med Sci Sports Exerc. 1997 Aug;29(8):1036-9 - PubMed
  110. J Appl Physiol (1985). 1985 Oct;59(4):1298-303 - PubMed
  111. N Engl J Med. 1987 Sep 10;317(11):687-94 - PubMed
  112. J Strength Cond Res. 2007 Feb;21(1):118-22 - PubMed
  113. Med Sci Sports Exerc. 2007 Jul;39(7):1107-13 - PubMed
  114. J Biol Chem. 2002 Nov 22;277(47):44784-90 - PubMed
  115. Med Sci Sports Exerc. 2006 Aug;38(8):1436-42 - PubMed
  116. Sports Med. 2006;36(4):327-58 - PubMed
  117. Int J Sport Nutr Exerc Metab. 2006 Jun;16(3):270-80 - PubMed
  118. J Appl Physiol (1985). 1993 Feb;74(2):965-9 - PubMed
  119. Ann N Y Acad Sci. 2006 May;1067:10-21 - PubMed
  120. Eur J Appl Physiol. 2009 Nov;107(5):587-95 - PubMed
  121. Acta Physiol (Oxf). 2018 Feb;222(2):null - PubMed
  122. J Appl Physiol (1985). 1988 Jan;64(1):115-9 - PubMed
  123. Med Sci Sports Exerc. 2010 Jul;42(7):1388-95 - PubMed
  124. Biochem Biophys Res Commun. 1992 Dec 15;189(2):801-6 - PubMed
  125. Free Radic Res. 1997 Dec;27(6):607-18 - PubMed
  126. Am J Physiol. 1993 May;264(5 Pt 2):R992-8 - PubMed
  127. Med Sci Sports Exerc. 2007 Feb;39(2):283-8 - PubMed
  128. PLoS One. 2015 Nov 05;10(11):e0141780 - PubMed
  129. Eur J Appl Physiol Occup Physiol. 1987;56(3):313-6 - PubMed
  130. Nature. 1954 Oct 9;174(4432):689-91 - PubMed
  131. J Appl Physiol (1985). 2000 Jul;89(1):21-8 - PubMed
  132. Sports Med. 2011 Dec 1;41(12):1043-69 - PubMed
  133. J Appl Physiol (1985). 2008 Jun;104(6):1611-7 - PubMed
  134. Int J Biochem Cell Biol. 2007;39(1):44-84 - PubMed
  135. J Appl Physiol (1985). 1994 Nov;77(5):2177-87 - PubMed
  136. Dyn Med. 2009 Jan 13;8:1 - PubMed
  137. Int J Sports Med. 1996 Aug;17(6):397-403 - PubMed
  138. J Appl Physiol (1985). 1990 May;68(5):2107-13 - PubMed
  139. J Nutr. 1979 Jun;109(6):1103-9 - PubMed

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