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Knudsen A, Thorsteinsson K, Christensen TE, et al. Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G. Open Forum Infect Dis. 2018;5(9):ofy205doi: 10.1093/ofid/ofy205.
Knudsen, A., Thorsteinsson, K., Christensen, T. E., Hasbak, P., Ripa, R. S., Panum, I., Lebech, A. M., & Kjaer, A. (2018). Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G. Open forum infectious diseases, 5(9), ofy205. https://doi.org/10.1093/ofid/ofy205
Knudsen, Andreas, et al. "Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G." Open forum infectious diseases vol. 5,9 (2018): ofy205. doi: https://doi.org/10.1093/ofid/ofy205
Knudsen A, Thorsteinsson K, Christensen TE, Hasbak P, Ripa RS, Panum I, Lebech AM, Kjaer A. Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G. Open Forum Infect Dis. 2018 Sep 11;5(9):ofy205. doi: 10.1093/ofid/ofy205. eCollection 2018 Sep. PMID: 30214912; PMCID: PMC6132927.
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Open Forum Infect Dis. 2018 Sep 11;5(9):ofy205. doi: 10.1093/ofid/ofy205. eCollection 2018 Sep.

Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G.

Open forum infectious diseases

Andreas Knudsen, Kristina Thorsteinsson, Thomas E Christensen, Philip Hasbak, Rasmus Sejersten Ripa, Inge Panum, Anne-Mette Lebech, Andreas Kjaer

Affiliations

  1. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark.
  2. Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  3. Cluster for Molecular Imaging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
  4. Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, Denmark.
  5. Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

PMID: 30214912 PMCID: PMC6132927 DOI: 10.1093/ofid/ofy205

Abstract

BACKGROUND: People living with HIV (PLWH) appear to be at increased risk of cardiovascular disease (CVD), and this is possibly more pronounced in women living with HIV (WLWH). In the general population, men are more likely to develop obstructive coronary artery disease (CAD), and women often present with a nonobstructive pattern with cardiac microvascular dysfunction. We investigated cardiac microvascular function in men and women living with HIV and tested for association with cytomegalovirus (CMV) immunoglobulin G (IgG), as this has been associated with CVD in PLWH.

METHODS: In a cross-sectional study, 94 PLWH on antiretroviral therapy were scanned with

RESULTS: WLWH had significantly lower MFR compared with men living with HIV (MLWH;

CONCLUSIONS: In this first study comparing MFR in women and men living with HIV, we found that WLWH had significantly lower MFR than MLWH and 45% of the women had cardiac microvascular dysfunction despite younger age and lower cardiovascular risk. Furthermore, CMV IgG was inversely associated with MFR among women but not men. This calls for attention to CVD among young WLWH even with low cardiovascular risk.

Keywords: HIV; cardiac microvascular; cytomegalovirus

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