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Sempoux C, Balabaud C, Bioulac-Sage P. Malignant transformation of hepatocellular adenoma. Hepat Oncol. 2014;1(4):421-431doi: 10.2217/hep.14.14.
Sempoux, C., Balabaud, C., & Bioulac-Sage, P. (2014). Malignant transformation of hepatocellular adenoma. Hepatic oncology, 1(4), 421-431. https://doi.org/10.2217/hep.14.14
Sempoux, Christine, et al. "Malignant transformation of hepatocellular adenoma." Hepatic oncology vol. 1,4 (2014): 421-431. doi: https://doi.org/10.2217/hep.14.14
Sempoux C, Balabaud C, Bioulac-Sage P. Malignant transformation of hepatocellular adenoma. Hepat Oncol. 2014 Oct;1(4):421-431. doi: 10.2217/hep.14.14. Epub 2014 Dec 11. PMID: 30190977; PMCID: PMC6095435.
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Hepat Oncol. 2014 Oct;1(4):421-431. doi: 10.2217/hep.14.14. Epub 2014 Dec 11.

Malignant transformation of hepatocellular adenoma.

Hepatic oncology

Christine Sempoux, Charles Balabaud, Paulette Bioulac-Sage

Affiliations

  1. Service d'Anatomie Pathologique, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, B-1200 Brussels, Belgium.
  2. Institut National de la Santé et de la Recherche Médicale (Inserm) 1053, Université de Bordeaux, Bordeaux, France.

PMID: 30190977 PMCID: PMC6095435 DOI: 10.2217/hep.14.14

Abstract

Hepatocellular adenomas carry a risk of malignant transformation. However, little is known about the rate of this risk, the predisposing factors, the histological and/or immunohistochemical markers and the precursor lesions. Even the pathogenesis of malignant transformation itself is poorly understood. This review details the current knowledge on the subject.

Keywords: hepatocellular adenoma; hepatocellular carcinoma; histopathology; immunohistochemistry; malignant transformation; β-catenin activation

Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with th

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