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Front Psychiatry. 2018 Sep 07;9:424. doi: 10.3389/fpsyt.2018.00424. eCollection 2018.

Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression.

Frontiers in psychiatry

Johannes A C Laferton, Sagar Vijapura, Lee Baer, Alisabet J Clain, Abigail Cooper, George Papakostas, Lawrence H Price, Linda L Carpenter, Audrey R Tyrka, Maurizio Fava, David Mischoulon

Affiliations

  1. Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Harvard University, Boston, MA, United States.
  2. Department of Clinical Psychology and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
  3. Department of Clinical Psychology and Psychotherapy, Psychologische Hochschule Berlin, Berlin, Germany.
  4. Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
  5. Mood Disorders Research Program, Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, United States.

PMID: 30245644 PMCID: PMC6137256 DOI: 10.3389/fpsyt.2018.00424

[No abstract available.]

Keywords: SAMe; bias; double blind randomized controlled trial; escitalopram; major depressive disorder; perceived treatment assignment; placebo; un-blinding

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