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Saponaro F, Saba A, Frascarelli S, et al. Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocr Connect. 2018;7(9):957-964doi: 10.1530/EC-18-0207.
Saponaro, F., Saba, A., Frascarelli, S., Frontera, C., Clerico, A., Scalese, M., Sessa, M. R., Cetani, F., Borsari, S., Pardi, E., Marvelli, A., Marcocci, C., Passino, C., & Zucchi, R. (2018). Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocrine connections, 7(9), 957-964. https://doi.org/10.1530/EC-18-0207
Saponaro, Federica, et al. "Vitamin D measurement and effect on outcome in a cohort of patients with heart failure." Endocrine connections vol. 7,9 (2018): 957-964. doi: https://doi.org/10.1530/EC-18-0207
Saponaro F, Saba A, Frascarelli S, Frontera C, Clerico A, Scalese M, Sessa MR, Cetani F, Borsari S, Pardi E, Marvelli A, Marcocci C, Passino C, Zucchi R. Vitamin D measurement and effect on outcome in a cohort of patients with heart failure. Endocr Connect. 2018 Sep 01;7(9):957-964. doi: 10.1530/EC-18-0207. PMID: 30300540; PMCID: PMC6176284.
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Endocr Connect. 2018 Sep 01;7(9):957-964. doi: 10.1530/EC-18-0207.

Vitamin D measurement and effect on outcome in a cohort of patients with heart failure.

Endocrine connections

Federica Saponaro, Alessandro Saba, Sabina Frascarelli, Concetta Frontera, Aldo Clerico, Marco Scalese, Maria Rita Sessa, Filomena Cetani, Simona Borsari, Elena Pardi, Antonella Marvelli, Claudio Marcocci, Claudio Passino, Riccardo Zucchi

PMID: 30300540 PMCID: PMC6176284 DOI: 10.1530/EC-18-0207

Abstract

OBJECTIVES: The aims of this paper were to evaluate the levels of Vitamin D (VitD) in patients with heart failure (HF), compared to a control group, to assess the effects of VitD on HF outcome and to compare VitD measurement between LIAISON immunoassay and HPLC-MS-MS methods in this population.

DESIGN AND METHODS: We collected clinical, biochemical and outcome data from 247 patients with HF and in a subgroup of 151 patients, we measured VitD both with LIAISON and HPLC-MS-MS.

RESULTS: HF patients had statistically lower 25OHD levels (45.2 ± 23.7 nmol/L vs 58.2 ± 24.0 nmol/L, P < 0.001) and a statistically higher prevalence of VitD insufficiency (61.1% vs 39.5%, P < 0.001) and deficiency (24.7% vs 6.6%, P < 0.001), compared to healthy controls. There was a significant inverse relationship between baseline 25OHD and risk of HF-related death, with a HR of 0.59 (95% CI 0.37–0.92, P = 0.02), confirmed in a multivariate adjusted analysis. Kaplan–Meier survival analyses showed that VitD insufficiency was associated with reduced survival in HF patients (log rank P = 0.017). There was a good agreement between LIAISON and HPLC-MS-MS (Cohen’s kappa coefficient 0.70), but the prevalence of VitD insufficiency was significantly higher with the former compared to the latter method (58.3%, n = 88 vs 55.6%, n = 84, P < 0.001). LIAISON underestimated the 25OHD levels and showed a mean relative bias of −0.739% with 95% of limits of agreement (−9.00 to +7.52%), when compared to HPLC-MS-MS.

CONCLUSIONS: 25OHD levels adequately measured by HPLC-MS-MS showed to be low in HF population and to be correlated with HF-related risk of death.

© 2018 The authors

Keywords: vitamin D; 25-hydroxyvitamin D; mass spectrometry coupled to high performances liquid chromatography; immunoassay; hypovitaminosis D

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