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Pifferi F, Terrien J, Marchal J, et al. Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Commun Biol. 2018;1:30doi: 10.1038/s42003-018-0024-8.
Pifferi, F., Terrien, J., Marchal, J., Dal-Pan, A., Djelti, F., Hardy, I., Chahory, S., Cordonnier, N., Desquilbet, L., Hurion, M., Zahariev, A., Chery, I., Zizzari, P., Perret, M., Epelbaum, J., Blanc, S., Picq, J. L., Dhenain, M., & Aujard, F. (2018). Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Communications biology, 130. https://doi.org/10.1038/s42003-018-0024-8
Pifferi, Fabien, et al. "Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates." Communications biology vol. 1 (2018): 30. doi: https://doi.org/10.1038/s42003-018-0024-8
Pifferi F, Terrien J, Marchal J, Dal-Pan A, Djelti F, Hardy I, Chahory S, Cordonnier N, Desquilbet L, Hurion M, Zahariev A, Chery I, Zizzari P, Perret M, Epelbaum J, Blanc S, Picq JL, Dhenain M, Aujard F. Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates. Commun Biol. 2018 Apr 05;1:30. doi: 10.1038/s42003-018-0024-8. eCollection 2018. PMID: 30271916; PMCID: PMC6123706.
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Commun Biol. 2018 Apr 05;1:30. doi: 10.1038/s42003-018-0024-8. eCollection 2018.

Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates.

Communications biology

Fabien Pifferi, Jérémy Terrien, Julia Marchal, Alexandre Dal-Pan, Fathia Djelti, Isabelle Hardy, Sabine Chahory, Nathalie Cordonnier, Loïc Desquilbet, Murielle Hurion, Alexandre Zahariev, Isabelle Chery, Philippe Zizzari, Martine Perret, Jacques Epelbaum, Stéphane Blanc, Jean-Luc Picq, Marc Dhenain, Fabienne Aujard

Affiliations

  1. UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800, Brunoy, France.
  2. Unité d' Ophtalmologie, Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, 7 Avenue du Général de Gaulle, 94704, Maisons-Alfort, France.
  3. Histology and Pathology Department, Veterinary School of Alfort, PRES Paris Est, 94704, Maisons-Alfort, France.
  4. Service de Biostatistique et d'Épidémiologie Clinique, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94704, France.
  5. Université de Strasbourg, IPHC, 23 rue Becquerel, 67087, Strasbourg, France.
  6. CNRS, UMR7178, 23 rue Becquerel, 67087, Strasbourg, France.
  7. Unité Mixte de Recherche en Santé 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, 102-108 rue de la Santé, Paris, 75014, France.
  8. Laboratoire de Psychopathologie et de Neuropsychologie, EA 2027, Université Paris 8, 2 rue de la Liberté, 93000, St Denis, France.
  9. Neurodegenerative Diseases Laboratory, CNRS, CEA, Université Paris-Sud, Université Paris-Saclay UMR 9199, 92265, Fontenay-aux-Roses, France.
  10. Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Molecular Imaging Research Center (MIRCen), 92265, Fontenay-aux-Roses, France.
  11. UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800, Brunoy, France. [email protected].

PMID: 30271916 PMCID: PMC6123706 DOI: 10.1038/s42003-018-0024-8

Abstract

The health benefits of chronic caloric restriction resulting in lifespan extension are well established in many short-lived species, but the effects in humans and other primates remain controversial. Here we report the most advanced survival data and the associated follow-up to our knowledge of age-related alterations in a cohort of grey mouse lemurs (

Conflict of interest statement

The authors declare no competing interests.

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