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Enriquez JS, Yu M, Bouley BS, et al. Copper(ii) complexes for cysteine detection using . Dalton Trans. 2018;47(42):15024-15030doi: 10.1039/c8dt03780a.
Enriquez, J. S., Yu, M., Bouley, B. S., Xie, D., & Que, E. L. (2018). Copper(ii) complexes for cysteine detection using . Dalton transactions (Cambridge, England : 2003), 47(42), 15024-15030. https://doi.org/10.1039/c8dt03780a
Enriquez, José S, et al. "Copper(ii) complexes for cysteine detection using ." Dalton transactions (Cambridge, England : 2003) vol. 47,42 (2018): 15024-15030. doi: https://doi.org/10.1039/c8dt03780a
Enriquez JS, Yu M, Bouley BS, Xie D, Que EL. Copper(ii) complexes for cysteine detection using . Dalton Trans. 2018 Oct 30;47(42):15024-15030. doi: 10.1039/c8dt03780a. PMID: 30303220; PMCID: PMC6242275.
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Dalton Trans. 2018 Oct 30;47(42):15024-15030. doi: 10.1039/c8dt03780a.

Copper(ii) complexes for cysteine detection using .

Dalton transactions (Cambridge, England : 2003)

José S Enriquez, Meng Yu, Bailey S Bouley, Da Xie, Emily L Que

Affiliations

  1. Department of Chemistry, The University of Texas at Austin, 105 E. 24th St Stop A5300, Austin, Texas 78712, USA. [email protected].

PMID: 30303220 PMCID: PMC6242275 DOI: 10.1039/c8dt03780a

Abstract

Cysteine plays an essential role in maintaining cellular redox homeostasis and perturbations in cysteine concentration are associated with cardiovascular disease, liver disease, and cancer. 19F MRI is a promising modality for detecting cysteine in biology due to its high tissue penetration and negligible biological background signal. Herein we report fluorinated macrocyclic copper complexes that display a 19F NMR/MRI turn-on response following reduction of the Cu(ii) complexes by cysteine. The reactivity with cysteine was studied by monitoring the appearance of a robust diamagnetic 19F signal following addition of cysteine in conjunction with UV-vis and EPR spectroscopies. Importantly, complexes with -CH2CF3 tags display good water solubility. Studies with this complex in HeLa cells demonstrate the applicability of these probes to detect cysteine in complex biological environments.

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