Display options
Share it on

Adv Biosyst. 2017 Oct;1(10). doi: 10.1002/adbi.201700083. Epub 2017 Aug 18.

Embedded Spheroids as Models of the Cancer Microenvironment.

Advanced biosystems

Kristie M Tevis, Yolonda L Colson, Mark W Grinstaff

Affiliations

  1. Departments of Biomedical Engineering, Chemistry, and Medicine, Metcalf Center for Science and Engineering, Boston University, Boston, MA 02215.
  2. Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02215.

PMID: 30221187 PMCID: PMC6135264 DOI: 10.1002/adbi.201700083

Abstract

To more accurately study the complex mechanisms behind cancer invasion, progression, and response to treatment, researchers require models that replicate both the multicellular nature and 3D stromal environment present in an

Keywords: aggregates; cancer; cell clusters; multicellular; spheroids; tumoroids

References

  1. Nat Rev Cancer. 2005 Oct;5(10):786-95 - PubMed
  2. Int J Radiat Biol. 2007 Nov-Dec;83(11-12):849-71 - PubMed
  3. J Thorac Cardiovasc Surg. 2015 May;149(5):1417-24; discussion 1424-25.e1 - PubMed
  4. Langmuir. 2015 Dec 1;31(47):12984-92 - PubMed
  5. Oncotarget. 2015 Aug 28;6(25):21655-74 - PubMed
  6. Transl Oncol. 2011 Dec;4(6):365-76 - PubMed
  7. Biomaterials. 2005 May;26(15):2467-77 - PubMed
  8. J Biosci Bioeng. 2011 Sep;112(3):265-72 - PubMed
  9. Tissue Eng Part A. 2010 Jan;16(1):101-14 - PubMed
  10. J Neurosurg. 2007 Feb;106(2):306-13 - PubMed
  11. J Cell Biol. 1983 May;96(5):1425-34 - PubMed
  12. Cancer Res. 2010 May 15;70(10):4141-50 - PubMed
  13. Circ Res. 2007 Jul 6;101(1):59-68 - PubMed
  14. J Cell Biol. 1998 Nov 30;143(5):1341-52 - PubMed
  15. Semin Cancer Biol. 2008 Oct;18(5):356-64 - PubMed
  16. Cell Mol Bioeng. 2015 Mar;8(1):76-85 - PubMed
  17. Lab Invest. 2012 Jul;92(7):988-98 - PubMed
  18. Semin Cell Dev Biol. 2010 Feb;21(1):2-10 - PubMed
  19. Biomaterials. 2015 Nov;69:99-109 - PubMed
  20. Theranostics. 2012;2(1):66-75 - PubMed
  21. Biosens Bioelectron. 2013 Apr 15;42:300-7 - PubMed
  22. Cancer Res. 2008 Jul 15;68(14):5743-52 - PubMed
  23. Anal Biochem. 2016 Dec 15;515:47-54 - PubMed
  24. Cancer Lett. 2010 Jun 28;292(2):215-27 - PubMed
  25. Mol Cell Proteomics. 2013 Dec;12(12):3778-92 - PubMed
  26. Int J Cancer. 2009 May 1;124(9):2060-70 - PubMed
  27. Cell Microbiol. 2009 Jul;11(7):1088-101 - PubMed
  28. Curr Pharm Biotechnol. 2009 Feb;10(2):185-91 - PubMed
  29. Nat Rev Cancer. 2004 Nov;4(11):839-49 - PubMed
  30. Cancer Res. 2003 Dec 15;63(24):8634-47 - PubMed
  31. PLoS One. 2014 May 08;9(5):e96426 - PubMed
  32. Breast Cancer Res Treat. 2006 Mar;96(2):169-76 - PubMed
  33. Lung Cancer. 2015 Oct;90(1):22-31 - PubMed
  34. PLoS One. 2014 Feb 28;9(2):e90371 - PubMed
  35. Clin Exp Metastasis. 2013 Jun;30(5):615-30 - PubMed
  36. J Control Release. 2010 Dec 1;148(2):135-46 - PubMed
  37. J Nucl Med. 2012 Jul;53(7):1135-45 - PubMed
  38. Neoplasia. 2000 Nov-Dec;2(6):496-504 - PubMed
  39. Neoplasia. 2007 Oct;9(10):840-52 - PubMed
  40. Cell Prolif. 2001 Apr;34(2):115-34 - PubMed
  41. Acta Biomater. 2013 Jan;9(1):4635-44 - PubMed
  42. Int J Cancer. 1994 Jan 15;56(2):255-61 - PubMed
  43. J Biomol Screen. 2007 Feb;12(1):13-20 - PubMed
  44. Cancer Res. 2016 Jul 1;76(13):3732-43 - PubMed
  45. PLoS One. 2016 Mar 16;11(3):e0150044 - PubMed
  46. Cell. 2004 Jul 23;118(2):217-28 - PubMed
  47. J Neurosurg. 1997 Oct;87(4):602-9 - PubMed
  48. Biomaterials. 2012 Mar;33(7):2165-76 - PubMed
  49. Angiogenesis. 2010 Dec;13(4):305-15 - PubMed
  50. J Biomol Screen. 2011 Feb;16(2):141-54 - PubMed
  51. J Control Release. 2012 Dec 10;164(2):192-204 - PubMed
  52. Chin Med J (Engl). 2012 Sep;125(18):3305-11 - PubMed
  53. Cancer Sci. 2010 Dec;101(12):2637-43 - PubMed
  54. J Neurooncol. 2004 May;67(3):295-303 - PubMed
  55. FEBS Lett. 2005 Oct 10;579(24):5338-42 - PubMed
  56. Cell Death Dis. 2013 Jul 11;4:e719 - PubMed
  57. Cells Tissues Organs. 2005;181(2):80-8 - PubMed
  58. Eur Cell Mater. 2012 Jun 05;23:387-99 - PubMed
  59. Cell Tissue Res. 2014 Jul;357(1):91-9 - PubMed
  60. Biochem Pharmacol. 2012 Mar 1;83(5):616-26 - PubMed
  61. Endocrinology. 1991 Jan;128(1):211-9 - PubMed
  62. Biochem Biophys Res Commun. 2013 May 24;435(1):58-63 - PubMed
  63. PLoS One. 2009;4(2):e4632 - PubMed
  64. Lab Chip. 2009 Dec 7;9(23):3378-84 - PubMed
  65. Biochem Biophys Res Commun. 2013 Apr 12;433(3):327-32 - PubMed
  66. Oncogene. 2013 Aug 1;32(31):3606-15 - PubMed
  67. Biochem Biophys Res Commun. 2007 Jul 27;359(2):263-8 - PubMed
  68. J Natl Cancer Inst. 1971 Jan;46(1):113-20 - PubMed
  69. FASEB J. 2015 Jul;29(7):3076-84 - PubMed
  70. J Cell Biochem. 2013 Apr;114(4):831-43 - PubMed
  71. Nat Med. 2000 Apr;6(4):389-95 - PubMed
  72. Am J Pathol. 1993 Nov;143(5):1406-15 - PubMed
  73. Immunobiology. 2010 Sep-Oct;215(9-10):737-47 - PubMed
  74. J Clin Invest. 2005 Sep;115(9):2382-92 - PubMed
  75. Semin Cancer Biol. 2005 Oct;15(5):405-12 - PubMed
  76. Exp Cell Res. 1996 Mar 15;223(2):357-71 - PubMed
  77. Acta Biomater. 2015 Mar;15:65-76 - PubMed
  78. Biomaterials. 2014 Feb;35(7):2264-71 - PubMed
  79. J Neurosci Methods. 2015 May 15;246:97-105 - PubMed
  80. Br J Cancer. 2006 Jan 16;94(1):101-7 - PubMed
  81. Biomaterials. 2009 Oct;30(28):4851-8 - PubMed
  82. Lab Invest. 2005 May;85(5):643-54 - PubMed
  83. Breast Cancer Res Treat. 2014 Nov;148(1):7-18 - PubMed
  84. Mol Cancer Ther. 2013 Oct;12(10):2176-86 - PubMed
  85. Am J Pathol. 2005 Apr;166(4):1077-88 - PubMed
  86. Tissue Eng. 2007 Dec;13(12):2863-70 - PubMed
  87. Acta Neuropathol. 1990;81(2):130-40 - PubMed
  88. FASEB J. 2001 Feb;15(2):447-57 - PubMed
  89. Acta Biomater. 2017 Mar 1;50:271-279 - PubMed
  90. J Appl Toxicol. 2015 Aug;35(8):909-17 - PubMed
  91. Nat Commun. 2013;4:1847 - PubMed
  92. J Neurosurg. 1999 Dec;91(6):989-96 - PubMed
  93. Br J Pharmacol. 2012 Nov;167(6):1218-31 - PubMed
  94. Biomaterials. 2010 Nov;31(32):8494-506 - PubMed
  95. PLoS One. 2015 Oct 07;10(10):e0139515 - PubMed
  96. Sci Rep. 2017 Sep 4;7(1):10382 - PubMed
  97. Biol Chem. 2008 Aug;389(8):1067-74 - PubMed
  98. Colloids Surf B Biointerfaces. 2009 Apr 1;70(1):114-23 - PubMed
  99. Nat Rev Cancer. 2003 Jun;3(6):401-10 - PubMed
  100. Ann N Y Acad Sci. 2005 Nov;1059:16-25 - PubMed
  101. Glia. 2009 Apr 1;57(5):561-81 - PubMed
  102. Breast Cancer Res Treat. 2011 Aug;128(3):657-66 - PubMed
  103. Mol Cancer. 2011 Sep 14;10:114 - PubMed
  104. PLoS One. 2012;7(2):e30753 - PubMed
  105. Biomaterials. 2012 Jan;33(1):181-8 - PubMed
  106. J Cell Biol. 1997 Apr 7;137(1):231-45 - PubMed
  107. Pathol Oncol Res. 2009 Dec;15(4):711-23 - PubMed
  108. Stem Cells Dev. 2013 Dec 1;22(23):3087-99 - PubMed
  109. Angiogenesis. 2004;7(2):115-22 - PubMed
  110. Cancer Res. 1977 Oct;37(10):3639-43 - PubMed
  111. Biomed Microdevices. 2014 Aug;16(4):609-15 - PubMed
  112. Microvasc Res. 2002 May;63(3):304-15 - PubMed
  113. Ann N Y Acad Sci. 1999 Jun 30;880:83-93 - PubMed
  114. Clin Exp Metastasis. 2004;21(8):685-97 - PubMed
  115. Cell Oncol (Dordr). 2012 Feb;35(1):19-28 - PubMed
  116. J Biotechnol. 2006 Apr 10;122(3):372-81 - PubMed
  117. Chin Med J (Engl). 2010 Jul;123(14):1871-7 - PubMed
  118. Biomaterials. 2008 Aug;29(22):3237-44 - PubMed
  119. Biotechnol J. 2016 Jan;11(1):127-34 - PubMed
  120. Endocrinology. 1990 Nov;127(5):2104-10 - PubMed
  121. Nano Lett. 2007 Dec;7(12):3759-65 - PubMed
  122. PLoS One. 2013 Dec 03;8(12):e80447 - PubMed
  123. Cancer Res. 2009 Mar 15;69(6):2224-33 - PubMed
  124. Photochem Photobiol. 2011 Mar-Apr;87(2):408-17 - PubMed
  125. J Neurobiol. 2004 Jul;60(1):71-88 - PubMed
  126. J Cell Sci. 1999 Oct;112 ( Pt 19):3249-58 - PubMed
  127. PLoS One. 2011;6(9):e24891 - PubMed
  128. PLoS One. 2013 Jul 29;8(7):e68575 - PubMed
  129. J Biomol Screen. 2006 Dec;11(8):922-32 - PubMed
  130. Blood. 2007 Feb 15;109(4):1472-8 - PubMed
  131. Oncogene. 2014 Apr 3;33(14):1850-61 - PubMed
  132. Endocrinology. 2004 Apr;145(4):1517-24 - PubMed
  133. Invasion Metastasis. 1995;15(5-6):179-88 - PubMed

Publication Types

Grant support