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Iacovacci V, Ricotti L, Sinibaldi E, et al. An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream. Adv Sci (Weinh). 2018;5(9):1800807doi: 10.1002/advs.201800807.
Iacovacci, V., Ricotti, L., Sinibaldi, E., Signore, G., Vistoli, F., & Menciassi, A. (2018). An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(9), 1800807. https://doi.org/10.1002/advs.201800807
Iacovacci, Veronica, et al. "An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 5,9 (2018): 1800807. doi: https://doi.org/10.1002/advs.201800807
Iacovacci V, Ricotti L, Sinibaldi E, Signore G, Vistoli F, Menciassi A. An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream. Adv Sci (Weinh). 2018 Aug 01;5(9):1800807. doi: 10.1002/advs.201800807. eCollection 2018 Sep. PMID: 30250809; PMCID: PMC6145422.
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Adv Sci (Weinh). 2018 Aug 01;5(9):1800807. doi: 10.1002/advs.201800807. eCollection 2018 Sep.

An Intravascular Magnetic Catheter Enables the Retrieval of Nanoagents from the Bloodstream.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Veronica Iacovacci, Leonardo Ricotti, Edoardo Sinibaldi, Giovanni Signore, Fabio Vistoli, Arianna Menciassi

Affiliations

  1. The BioRobotics Institute Scuola Superiore Sant'Anna Piazza Martiri della Libertà, 33 56127 Pisa PI Italy.
  2. Center for Micro-BioRobotics @SSSA Istituto Italiano di Tecnologia Viale Rinaldo Piaggio 34 56025 Pontedera Italy.
  3. Center of Nanotechnology Innovation@NEST Istituto Italiano di Tecnologia 56127 Pisa Italy.
  4. NEST Scuola Normale Superiore and Istituto Nanoscienze-CNR 56127 Pisa Italy.
  5. Division of General and Transplant Surgery Azienda Ospedaliera Universitaria PisanaUniversity of Pisa Via Paradisa 2 56124 Pisa Italy.

PMID: 30250809 PMCID: PMC6145422 DOI: 10.1002/advs.201800807

Abstract

The clinical adoption of nanoscale agents for targeted therapy is still hampered by the quest for a balance between therapy efficacy and side effects on healthy tissues, due to nanoparticle biodistribution and undesired drug accumulation issues. Here, an intravascular catheter able to efficiently retrieve from the bloodstream magnetic nanocarriers not contributing to therapy, thus minimizing their uncontrollable dispersion and consequently attenuating possible side effects, is proposed. The device consists of a miniature module, based on 27 permanent magnets arranged in two coaxial series, integrated into a clinically used 12 French catheter. This device can capture ≈94% and 78% of the unused agents when using as carriers 500 and 250 nm nominal diameter superparamagnetic iron oxide nanoparticles, respectively. This approach paves the way to the exploitation of new "high-risk/high-gain" drug formulations and supports the development of novel therapeutic strategies based on magnetic hyperthermia or magnetic microrobots.

Keywords: intravascular devices; magnetic nanoparticles; magnetic retrieval; targeted therapy

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