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Pfeiffer C, Nguissi NAN, Chytiris M, et al. Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. Ann Clin Transl Neurol. 2018;5(9):1016-1024doi: 10.1002/acn3.600.
Pfeiffer, C., Nguissi, N. A. N., Chytiris, M., Bidlingmeyer, P., Haenggi, M., Kurmann, R., Zubler, F., Accolla, E., Viceic, D., Rusca, M., Oddo, M., Rossetti, A. O., & De Lucia, M. (2018). Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. Annals of clinical and translational neurology, 5(9), 1016-1024. https://doi.org/10.1002/acn3.600
Pfeiffer, Christian, et al. "Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma." Annals of clinical and translational neurology vol. 5,9 (2018): 1016-1024. doi: https://doi.org/10.1002/acn3.600
Pfeiffer C, Nguissi NAN, Chytiris M, Bidlingmeyer P, Haenggi M, Kurmann R, Zubler F, Accolla E, Viceic D, Rusca M, Oddo M, Rossetti AO, De Lucia M. Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. Ann Clin Transl Neurol. 2018 Jul 26;5(9):1016-1024. doi: 10.1002/acn3.600. eCollection 2018 Sep. PMID: 30250859; PMCID: PMC6144443.
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Ann Clin Transl Neurol. 2018 Jul 26;5(9):1016-1024. doi: 10.1002/acn3.600. eCollection 2018 Sep.

Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma.

Annals of clinical and translational neurology

Christian Pfeiffer, Nathalie Ata Nguepnjo Nguissi, Magali Chytiris, Phanie Bidlingmeyer, Matthias Haenggi, Rebekka Kurmann, Frédéric Zubler, Ettore Accolla, Dragana Viceic, Marco Rusca, Mauro Oddo, Andrea O Rossetti, Marzia De Lucia

Affiliations

  1. Laboratoire de Recherche en Neuroimagerie (LREN) University Hospital (CHUV) & University of Lausanne Lausanne Switzerland.
  2. Department of Intensive Care Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland.
  3. Department of Neurology Inselspital Bern University Hospital University of Bern Bern Switzerland.
  4. Neurology Unit Department of Medicine Hôpital Cantonal Fribourg (HFR) Fribourg Switzerland.
  5. Laboratory for Cognitive and Neurological Sciences Department of Medicine University of Fribourg Fribourg Switzerland.
  6. Neurology Service Hôpital du Valais Sion Switzerland.
  7. Intensive Care Medicine Hôpital du Valais Sion Switzerland.
  8. Department of Intensive Care Medicine University Hospital (CHUV) & University of Lausanne Lausanne Switzerland.
  9. Neurology Service University Hospital (CHUV) & University of Lausanne Lausanne Switzerland.

PMID: 30250859 PMCID: PMC6144443 DOI: 10.1002/acn3.600

Abstract

OBJECTIVE: Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients.

METHODS: Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset.

RESULTS: Multivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68).

INTERPRETATION: Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.

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