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Huws SA, Creevey CJ, Oyama LB, et al. Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future. Front Microbiol. 2018;9:2161doi: 10.3389/fmicb.2018.02161.
Huws, S. A., Creevey, C. J., Oyama, L. B., Mizrahi, I., Denman, S. E., Popova, M., Muñoz-Tamayo, R., Forano, E., Waters, S. M., Hess, M., Tapio, I., Smidt, H., Krizsan, S. J., Yáñez-Ruiz, D. R., Belanche, A., Guan, L., Gruninger, R. J., McAllister, T. A., Newbold, C. J., Roehe, R., Dewhurst, R. J., Snelling, T. J., Watson, M., Suen, G., Hart, E. H., Kingston-Smith, A. H., Scollan, N. D., do Prado, R. M., Pilau, E. J., Mantovani, H. C., Attwood, G. T., Edwards, J. E., McEwan, N. R., Morrisson, S., Mayorga, O. L., Elliott, C., & Morgavi, D. P. (2018). Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future. Frontiers in microbiology, 92161. https://doi.org/10.3389/fmicb.2018.02161
Huws, Sharon A, et al. "Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future." Frontiers in microbiology vol. 9 (2018): 2161. doi: https://doi.org/10.3389/fmicb.2018.02161
Huws SA, Creevey CJ, Oyama LB, Mizrahi I, Denman SE, Popova M, Muñoz-Tamayo R, Forano E, Waters SM, Hess M, Tapio I, Smidt H, Krizsan SJ, Yáñez-Ruiz DR, Belanche A, Guan L, Gruninger RJ, McAllister TA, Newbold CJ, Roehe R, Dewhurst RJ, Snelling TJ, Watson M, Suen G, Hart EH, Kingston-Smith AH, Scollan ND, do Prado RM, Pilau EJ, Mantovani HC, Attwood GT, Edwards JE, McEwan NR, Morrisson S, Mayorga OL, Elliott C, Morgavi DP. Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future. Front Microbiol. 2018 Sep 25;9:2161. doi: 10.3389/fmicb.2018.02161. eCollection 2018. PMID: 30319557; PMCID: PMC6167468.
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Front Microbiol. 2018 Sep 25;9:2161. doi: 10.3389/fmicb.2018.02161. eCollection 2018.

Addressing Global Ruminant Agricultural Challenges Through Understanding the Rumen Microbiome: Past, Present, and Future.

Frontiers in microbiology

Sharon A Huws, Christopher J Creevey, Linda B Oyama, Itzhak Mizrahi, Stuart E Denman, Milka Popova, Rafael Muñoz-Tamayo, Evelyne Forano, Sinead M Waters, Matthias Hess, Ilma Tapio, Hauke Smidt, Sophie J Krizsan, David R Yáñez-Ruiz, Alejandro Belanche, Leluo Guan, Robert J Gruninger, Tim A McAllister, C Jamie Newbold, Rainer Roehe, Richard J Dewhurst, Tim J Snelling, Mick Watson, Garret Suen, Elizabeth H Hart, Alison H Kingston-Smith, Nigel D Scollan, Rodolpho M do Prado, Eduardo J Pilau, Hilario C Mantovani, Graeme T Attwood, Joan E Edwards, Neil R McEwan, Steven Morrisson, Olga L Mayorga, Christopher Elliott, Diego P Morgavi

Affiliations

  1. Institute for Global Food Security, Queen's University of Belfast, Belfast, United Kingdom.
  2. Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel.
  3. Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, Queensland Bioscience Precinct, St Lucia, QLD, Australia.
  4. Institute National de la Recherche Agronomique, UMR1213 Herbivores, Clermont Université, VetAgro Sup, UMR Herbivores, Clermont-Ferrand, France.
  5. UMR Modélisation Systémique Appliquée aux Ruminants, INRA, AgroParisTech, Université Paris-Saclay, Paris, France.
  6. UMR 454 MEDIS, INRA, Université Clermont Auvergne, Clermont-Ferrand, France.
  7. Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Ireland.
  8. College of Agricultural and Environmental Sciences, University of California, Davis, Davis, CA, United States.
  9. Natural Resources Institute Finland, Jokioinen, Finland.
  10. Department of Agrotechnology and Food Sciences, Wageningen, Netherlands.
  11. Department of Agricultural Research for Northern Sweden, Swedish University of Agricultural Sciences, Umeå, Sweden.
  12. Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Granada, Spain.
  13. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
  14. Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, AB, Canada.
  15. Scotland's Rural College, Edinburgh, United Kingdom.
  16. The Rowett Institute, University of Aberdeen, Aberdeen, United Kingdom.
  17. The Roslin Institute and the Royal (Dick) School of Veterinary Studies (R(D)SVS), University of Edinburgh, Edinburgh, United Kingdom.
  18. Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, United States.
  19. Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, United Kingdom.
  20. Laboratório de Biomoléculas e Espectrometria de Massas-Labiomass, Departamento de Química, Universidade Estadual de Maringá, Maringá, Brazil.
  21. Department of Microbiology, Universidade Federal de Viçosa, Viçosa, Brazil.
  22. AgResearch Limited, Grasslands Research Centre, Palmerston North, New Zealand.
  23. Laboratory of Microbiology, Wageningen University & Research, Wageningen, Netherlands.
  24. School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, United Kingdom.
  25. Sustainable Livestock, Agri-Food and Bio-Sciences Institute, Hillsborough, United Kingdom.
  26. Colombian Agricultural Research Corporation, Mosquera, Colombia.

PMID: 30319557 PMCID: PMC6167468 DOI: 10.3389/fmicb.2018.02161

Abstract

The rumen is a complex ecosystem composed of anaerobic bacteria, protozoa, fungi, methanogenic archaea and phages. These microbes interact closely to breakdown plant material that cannot be digested by humans, whilst providing metabolic energy to the host and, in the case of archaea, producing methane. Consequently, ruminants produce meat and milk, which are rich in high-quality protein, vitamins and minerals, and therefore contribute to food security. As the world population is predicted to reach approximately 9.7 billion by 2050, an increase in ruminant production to satisfy global protein demand is necessary, despite limited land availability, and whilst ensuring environmental impact is minimized. Although challenging, these goals can be met, but depend on our understanding of the rumen microbiome. Attempts to manipulate the rumen microbiome to benefit global agricultural challenges have been ongoing for decades with limited success, mostly due to the lack of a detailed understanding of this microbiome and our limited ability to culture most of these microbes outside the rumen. The potential to manipulate the rumen microbiome and meet global livestock challenges through animal breeding and introduction of dietary interventions during early life have recently emerged as promising new technologies. Our inability to phenotype ruminants in a high-throughput manner has also hampered progress, although the recent increase in "omic" data may allow further development of mathematical models and rumen microbial gene biomarkers as proxies. Advances in computational tools, high-throughput sequencing technologies and cultivation-independent "omics" approaches continue to revolutionize our understanding of the rumen microbiome. This will ultimately provide the knowledge framework needed to solve current and future ruminant livestock challenges.

Keywords: diet; host; methane; microbiome; omics; production; rumen

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