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Podfigurna A, Stellmach A, Szeliga A, et al. Metabolic Profile of Patients with Premature Ovarian Insufficiency. J Clin Med. 2018;7(10)doi: 10.3390/jcm7100374.
Podfigurna, A., Stellmach, A., Szeliga, A., Czyzyk, A., & Meczekalski, B. (2018). Metabolic Profile of Patients with Premature Ovarian Insufficiency. Journal of clinical medicine, 7(10), . https://doi.org/10.3390/jcm7100374
Podfigurna, Agnieszka, et al. "Metabolic Profile of Patients with Premature Ovarian Insufficiency." Journal of clinical medicine vol. 7,10 (2018). doi: https://doi.org/10.3390/jcm7100374
Podfigurna A, Stellmach A, Szeliga A, Czyzyk A, Meczekalski B. Metabolic Profile of Patients with Premature Ovarian Insufficiency. J Clin Med. 2018 Oct 21;7(10). doi: 10.3390/jcm7100374. PMID: 30347864; PMCID: PMC6210159.
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J Clin Med. 2018 Oct 21;7(10). doi: 10.3390/jcm7100374.

Metabolic Profile of Patients with Premature Ovarian Insufficiency.

Journal of clinical medicine

Agnieszka Podfigurna, Angelika Stellmach, Anna Szeliga, Adam Czyzyk, Blazej Meczekalski

Affiliations

  1. Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. [email protected].
  2. Students Scientific Society of the Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. [email protected].
  3. Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. [email protected].
  4. Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. [email protected].
  5. Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Polna 33, Poznan 60-535, Poland. [email protected].

PMID: 30347864 PMCID: PMC6210159 DOI: 10.3390/jcm7100374

Abstract

Premature ovarian insufficiency (POI) is hypogonadism associated with amenorrhea, increased levels of gonadotropins, and hypoestrogenism. Deficiency of estrogens may contribute to higher risk of cardiovascular diseases and death. POI patients present several risk factors for the development of cardiovascular diseases (CVD): endothelial dysfunction, abnormal lipid profile, insulin resistance, and insulin action disturbances. Therefore, patients present a higher risk of developing metabolic syndrome.

MATERIALS AND METHODS: Follicle stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol (E2), prolactin (PRL), testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), thyroxine (fT4), fasting serum glucose and insulin concentrations, homeostatic model for insulin resistance (HOMA-IR), and lipid profiles were assessed in 56 women (mean age: 30.7

RESULTS: After regression analysis with BMI and age correction, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) serum concentrations were found to be significantly higher in the POI group, when compared to healthy subjects, whilst triglycerides, glucose, insulin serum concentrations, HOMA-IR, as well as systolic (SBP) and diastolic blood pressure (DBP) did not differ significantly between both groups. A significant positive correlation was identified between TC and LDL-C levels, regardless of BMI and age, whilst SBP correlated only with serum glucose concentration. Additionally, FSH correlated positively with fasting serum glucose concentration after BMI and age correction.

CONCLUSIONS: Certain metabolic parameters appeared to correlate with POI and these correlations persisted after correction for BMI and age. More research is required to determine the influence of absent ovulatory function on metabolic profiles in POI women. This information may additionally help in early identification of CVD risk factors in those patients.

Keywords: cardiovascular risk; insulin resistance; lipid profile; premature ovarian insufficiency

References

  1. Hum Reprod. 2003 Jan;18(1):199-206 - PubMed
  2. Maturitas. 2010 Sep;67(1):91-3 - PubMed
  3. Am J Epidemiol. 2000 Mar 15;151(6):584-93 - PubMed
  4. Biol Trace Elem Res. 2013 Sep;154(3):313-20 - PubMed
  5. Menopause. 2008 Sep-Oct;15(5):919-23 - PubMed
  6. Semin Reprod Med. 2011 Jul;29(4):328-41 - PubMed
  7. Maturitas. 2014 Nov;79(3):306-10 - PubMed
  8. Lancet. 1996 Mar 16;347(9003):714-8 - PubMed
  9. J Korean Med Sci. 2000 Aug;15(4):380-6 - PubMed
  10. J Midlife Health. 2015 Oct-Dec;6(4):147-53 - PubMed
  11. Obstet Gynecol Clin North Am. 2003 Jun;30(2):287-302 - PubMed
  12. Maturitas. 2007 Sep 20;58(1):19-30 - PubMed
  13. J Clin Endocrinol Metab. 2004 Aug;89(8):3907-13 - PubMed
  14. Hum Reprod. 2016 May;31(5):926-37 - PubMed
  15. J Clin Endocrinol Metab. 2016 Sep;101(9):3306-15 - PubMed
  16. Menopause. 2012 Jul;19(7):760-7 - PubMed
  17. Menopause. 2006 Nov-Dec;13(6):911-6 - PubMed
  18. J Clin Epidemiol. 1997 Apr;50(4):475-9 - PubMed
  19. J Endocrinol Invest. 2016 Sep;39(9):983-90 - PubMed
  20. Obstet Gynecol. 1986 Apr;67(4):604-6 - PubMed
  21. Menopause. 2012 Nov;19(11):1231-4 - PubMed
  22. N Engl J Med. 2009 Feb 5;360(6):606-14 - PubMed
  23. Fertil Steril. 1967 Jul-Aug;18(4):440-61 - PubMed
  24. J Clin Epidemiol. 1999 Apr;52(4):303-7 - PubMed

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