Display options
Cite
Agabio R, Leggio L. Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders. Front Psychiatry. 2018;9:464doi: 10.3389/fpsyt.2018.00464.
Agabio, R., & Leggio, L. (2018). Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders. Frontiers in psychiatry, 9464. https://doi.org/10.3389/fpsyt.2018.00464
Agabio, Roberta, and Leggio, Lorenzo. "Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders." Frontiers in psychiatry vol. 9 (2018): 464. doi: https://doi.org/10.3389/fpsyt.2018.00464
Agabio R, Leggio L. Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders. Front Psychiatry. 2018 Sep 28;9:464. doi: 10.3389/fpsyt.2018.00464. eCollection 2018. PMID: 30323774; PMCID: PMC6172346.
Copy Download .nbib Format: NLM
Share it on

Front Psychiatry. 2018 Sep 28;9:464. doi: 10.3389/fpsyt.2018.00464. eCollection 2018.

Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders.

Frontiers in psychiatry

Roberta Agabio, Lorenzo Leggio

Affiliations

  1. Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy.
  2. Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, United States.
  3. Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.
  4. Center for Alcohol and Addiction Studies, Brown University, Providence, RI, United States.

PMID: 30323774 PMCID: PMC6172346 DOI: 10.3389/fpsyt.2018.00464

Abstract

A limited number of medications are approved to treat Alcohol Use Disorder (AUD). Furthermore, the magnitude of their therapeutic effect is relatively modest, suggesting the potential for subtypes of patients who respond to a specific medication. The use of these medications is also limited in clinical practice by a series of contraindications such as medical comorbidities and/or concurrent use of other medications. In recent years, animal and human studies have been conducted to evaluate the efficacy of baclofen, a GABA

Keywords: GABAB; alcohol use disorder; anxiety; baclofen; mental health disorders; mood disorders

References

  1. Eur Neuropsychopharmacol. 2016 Dec;26(12):1950-1959 - PubMed
  2. Alcohol Clin Exp Res. 2015 Mar;39(3):391-402 - PubMed
  3. Addiction. 2018 Aug;113(8):1396-1406 - PubMed
  4. Transl Psychiatry. 2017 Apr 25;7(4):e1108 - PubMed
  5. Alcohol Alcohol. 2007 Mar-Apr;42(2):158-60 - PubMed
  6. Addict Behav. 2015 Feb;41:46-50 - PubMed
  7. Am J Drug Alcohol Abuse. 2017 May;43(3):324-331 - PubMed
  8. Alcohol Clin Exp Res. 2010 Nov;34(11):1849-57 - PubMed
  9. Psychiatr Med. 1991;9(1):189-211 - PubMed
  10. J Dual Diagn. 2015;11(3-4):203-4 - PubMed
  11. Drug Saf. 2016 Jul;39(7):627-45 - PubMed
  12. Pharmacol Biochem Behav. 2013 Feb;103(4):784-91 - PubMed
  13. J Clin Psychopharmacol. 2012 Apr;32(2):266-8 - PubMed
  14. Expert Opin Pharmacother. 2017 Aug;18(12):1187-1199 - PubMed
  15. Arch Gen Psychiatry. 2007 Jul;64(7):830-42 - PubMed
  16. J Clin Psychopharmacol. 2007 Jun;27(3):319-20 - PubMed
  17. Drug Alcohol Depend. 1993 Sep;33(2):157-63 - PubMed
  18. Addiction. 2006 Sep;101 Suppl 1:76-88 - PubMed
  19. Lancet. 2007 Dec 8;370(9603):1915-22 - PubMed
  20. Neuropsychol Rev. 2009 Mar;19(1):115-29 - PubMed
  21. Expert Opin Drug Saf. 2018 Feb;17(2):169-177 - PubMed
  22. BMJ Case Rep. 2017 May 11;2017:null - PubMed
  23. Alcohol Alcohol. 2002 Sep-Oct;37(5):504-8 - PubMed
  24. J Subst Abuse Treat. 2015 May;52:24-30 - PubMed
  25. Eur Neuropsychopharmacol. 2015 Aug;25(8):1167-77 - PubMed
  26. Am J Psychiatry. 2018 Jan 1;175(1):86-90 - PubMed
  27. Indian J Psychol Med. 2015 Jul-Sep;37(3):370-3 - PubMed
  28. JAMA Psychiatry. 2015 Aug;72(8):757-66 - PubMed
  29. Alcohol Alcohol. 2014 Jul-Aug;49(4):453-6 - PubMed
  30. Ind Psychiatry J. 2016 Jan-Jun;25(1):11-16 - PubMed
  31. Front Psychiatry. 2014 Oct 10;5:143 - PubMed
  32. Cochrane Database Syst Rev. 2018 Apr 24;4:CD008581 - PubMed
  33. Eur Neuropsychopharmacol. 2018 Jul;28(7):795-806 - PubMed
  34. World J Biol Psychiatry. 2017 Mar;18(2):86-119 - PubMed
  35. Alcohol Clin Exp Res. 2016 Jul;40(7):1368-79 - PubMed
  36. Alcohol Alcohol. 2005 Mar-Apr;40(2):147-50 - PubMed
  37. Alcohol Alcohol. 2017 Jul 1;52(4):439-446 - PubMed
  38. Eur Psychiatry. 2000 May;15(3):160-72 - PubMed
  39. Front Psychiatry. 2012 Dec 03;3:103 - PubMed
  40. Am J Psychiatry. 2013 Jan;170(1):23-30 - PubMed
  41. Handb Exp Pharmacol. 2018 Jan 03;:null - PubMed
  42. Alcohol. 2008 Aug;42(5):375-81 - PubMed
  43. Br J Psychiatry. 2018 Jun;212(6):362-369 - PubMed
  44. Cochrane Database Syst Rev. 2015 Jan 20;1:CD007505 - PubMed
  45. Alcohol Alcohol. 2011 Nov-Dec;46(6):714-20 - PubMed
  46. JAMA. 2017 Jun 13;317(22):2267-2269 - PubMed
  47. Alcohol Clin Exp Res. 2004 Oct;28(10):1517-23 - PubMed
  48. Aliment Pharmacol Ther. 2017 Apr;45(7):865-882 - PubMed
  49. Lancet. 2016 Oct 8;388(10053):1603-1658 - PubMed
  50. Acta Psychiatr Scand. 2018 Sep;138(3):232-242 - PubMed
  51. Eur J Gastroenterol Hepatol. 2017 Oct;29(10):1155-1160 - PubMed
  52. Alcohol Alcohol. 2014 Nov;49(6):654-60 - PubMed
  53. Addiction. 2012 Apr;107(4):848-9 - PubMed
  54. Addiction. 2017 Jul;112(7):1173-1183 - PubMed
  55. Biol Psychiatry. 2018 Jun 1;83(11):963-976 - PubMed
  56. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):53-62 - PubMed
  57. Lancet. 2016 Oct 8;388(10053):1659-1724 - PubMed
  58. Int Clin Psychopharmacol. 2015 Jan;30(1):49-53 - PubMed
  59. Drug Alcohol Depend. 2009 Jan 1;99(1-3):345-9 - PubMed
  60. Alcohol Clin Exp Res. 2000 Jan;24(1):67-71 - PubMed
  61. Alcohol Alcohol. 2011 May-Jun;46(3):312-7 - PubMed
  62. Psychopharmacology (Berl). 2015 Jan;232(1):233-43 - PubMed
  63. Alcohol Alcohol. 2012 Jul-Aug;47(4):439-42 - PubMed

Publication Types

Grant support