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Maraolo AE, Gentile I, Buonomo AR, et al. Current evidence on the management of hepatitis B in pregnancy. World J Hepatol. 2018;10(9):585-594doi: 10.4254/wjh.v10.i9.585.
Maraolo, A. E., Gentile, I., Buonomo, A. R., Pinchera, B., & Borgia, G. (2018). Current evidence on the management of hepatitis B in pregnancy. World journal of hepatology, 10(9), 585-594. https://doi.org/10.4254/wjh.v10.i9.585
Maraolo, Alberto Enrico, et al. "Current evidence on the management of hepatitis B in pregnancy." World journal of hepatology vol. 10,9 (2018): 585-594. doi: https://doi.org/10.4254/wjh.v10.i9.585
Maraolo AE, Gentile I, Buonomo AR, Pinchera B, Borgia G. Current evidence on the management of hepatitis B in pregnancy. World J Hepatol. 2018 Sep 27;10(9):585-594. doi: 10.4254/wjh.v10.i9.585. PMID: 30310536; PMCID: PMC6177570.
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World J Hepatol. 2018 Sep 27;10(9):585-594. doi: 10.4254/wjh.v10.i9.585.

Current evidence on the management of hepatitis B in pregnancy.

World journal of hepatology

Alberto Enrico Maraolo, Ivan Gentile, Antonio Riccardo Buonomo, Biagio Pinchera, Guglielmo Borgia

Affiliations

  1. Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy. [email protected].
  2. Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy.

PMID: 30310536 PMCID: PMC6177570 DOI: 10.4254/wjh.v10.i9.585

Abstract

Hepatitis B virus (HBV) infection is one of the main public health problems across the globe, since almost one third of the world population presents serological markers of contact with the virus. A profound impact on the epidemiology has been exerted by universal vaccination programmes in many countries, nevertheless the infection is still widespread also in its active form. In the areas of high endemicity (prevalence of hepatitis B surface antigen positivity > 7%), mother-to-child transmission represents the main modality of infection spread. That makes the correct management of HBV in pregnancy a matter of utmost importance. Furthermore, the infection in pregnancy needs to be carefully assessed and handled not only with respect to the risk of vertical transmission but also with respect to gravid women health. Each therapeutic or preventive choice deserves to be weighed upon attentively. On many aspects evidence is scarce or controversial. This review will highlight the latest insights into the paramount steps in managing HBV in pregnancy, with particular attention to recommendations from recent guidelines and data from up-do-date research syntheses.

Keywords: Antiviral prophylaxis; Hepatitis B; Hepatitis B immunoglobulin; Immunoprophylaxis; Pregnancy; Therapy

Conflict of interest statement

Conflict-of-interest statement: The authors report no conflict of interest.

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