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Asadzadeh Manjili F, Kalantar SM, Arsang-Jang S, et al. Upregulation of vitamin D-related genes in schizophrenic patients. Neuropsychiatr Dis Treat. 2018;14:2583-2591doi: 10.2147/NDT.S176301.
Asadzadeh Manjili, F., Kalantar, S. M., Arsang-Jang, S., Ghafouri-Fard, S., Taheri, M., & Sayad, A. (2018). Upregulation of vitamin D-related genes in schizophrenic patients. Neuropsychiatric disease and treatment, 142583-2591. https://doi.org/10.2147/NDT.S176301
Asadzadeh Manjili, Fateme, et al. "Upregulation of vitamin D-related genes in schizophrenic patients." Neuropsychiatric disease and treatment vol. 14 (2018): 2583-2591. doi: https://doi.org/10.2147/NDT.S176301
Asadzadeh Manjili F, Kalantar SM, Arsang-Jang S, Ghafouri-Fard S, Taheri M, Sayad A. Upregulation of vitamin D-related genes in schizophrenic patients. Neuropsychiatr Dis Treat. 2018 Oct 09;14:2583-2591. doi: 10.2147/NDT.S176301. eCollection 2018. PMID: 30349256; PMCID: PMC6186300.
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Neuropsychiatr Dis Treat. 2018 Oct 09;14:2583-2591. doi: 10.2147/NDT.S176301. eCollection 2018.

Upregulation of vitamin D-related genes in schizophrenic patients.

Neuropsychiatric disease and treatment

Fateme Asadzadeh Manjili, Seyed Mehdi Kalantar, Shahram Arsang-Jang, Soudeh Ghafouri-Fard, Mohammad Taheri, Arezou Sayad

Affiliations

  1. Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  2. Reproductive and Genetic Unit, Recurrent Abortion Research Center, Yazd Reproductive Science Institute, Yazd University of Medical Sciences, Yazd, Iran.
  3. Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran.
  4. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, [email protected]; [email protected].
  5. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, [email protected].

PMID: 30349256 PMCID: PMC6186300 DOI: 10.2147/NDT.S176301

Abstract

INTRODUCTION: Low level of vitamin D is a potential risk factor for developing schizophrenia. Through interaction with its receptor (

METHODS: In this case-control study, relative expression of

RESULTS: Significant upregulations were observed in

CONCLUSION: We hypothesized that the observed upregulation of the mentioned genes in schizophrenia patients might be the result of a compensatory mechanism to protect the affected individuals against adverse consequences of this disorder. Such imbalance in vitamin D processing pathway might also be implicated in the pathogenesis of schizophrenia. However, future studies should be designed to confirm the results of the current study.

Keywords: CYP24A1; CYP27B1; VDR; schizophrenia

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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