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Pannunzio A, Coluccia M. Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. Pharmaceuticals (Basel). 2018;11(4)doi: 10.3390/ph11040101.
Pannunzio, A., & Coluccia, M. (2018). Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. Pharmaceuticals (Basel, Switzerland), 11(4), . https://doi.org/10.3390/ph11040101
Pannunzio, Alessandra, and Coluccia, Mauro. "Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature." Pharmaceuticals (Basel, Switzerland) vol. 11,4 (2018). doi: https://doi.org/10.3390/ph11040101
Pannunzio A, Coluccia M. Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. Pharmaceuticals (Basel). 2018 Oct 11;11(4). doi: 10.3390/ph11040101. PMID: 30314310; PMCID: PMC6316056.
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Pharmaceuticals (Basel). 2018 Oct 11;11(4). doi: 10.3390/ph11040101.

Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature.

Pharmaceuticals (Basel, Switzerland)

Alessandra Pannunzio, Mauro Coluccia

Affiliations

  1. Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, I-70125 Bari, Italy. [email protected].
  2. Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, I-70125 Bari, Italy. [email protected].

PMID: 30314310 PMCID: PMC6316056 DOI: 10.3390/ph11040101

Abstract

Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of cyclooxygenases (particularly COX-2) and prostaglandins (particularly PGE₂) in cancer-related inflammation has been extensively investigated. In contrast, COX-1 has received less attention, although its expression increases in several human cancers and a pathogenetic role emerges from experimental models. COX-1 and COX-2 isoforms seem to operate in a coordinate manner in cancer pathophysiology, especially in the tumorigenesis process. However, in some cases, exemplified by the serous ovarian carcinoma, COX-1 plays a pivotal role, suggesting that other histopathological and molecular subtypes of cancer disease could share this feature. Importantly, the analysis of functional implications of COX-1-signaling, as well as of pharmacological action of COX-1-selective inhibitors, should not be restricted to the COX pathway and to the effects of prostaglandins already known for their ability of affecting the tumor phenotype. A knowledge-based choice of the most appropriate tumor cell models, and a major effort in investigating the COX-1 issue in the more general context of arachidonic acid metabolic network by using the systems biology approaches, should be strongly encouraged.

Keywords: COX-1 inhibitor; cancer; cyclooxygenase-1; cyclooxygenase-2; inflammation; tumorigenesis

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