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Gassner C, Degenhardt F, Meyer S, et al. Low-Frequency Blood Group Antigens in Switzerland. Transfus Med Hemother. 2018;45(4):239-250doi: 10.1159/000490714.
Gassner, C., Degenhardt, F., Meyer, S., Vollmert, C., Trost, N., Neuenschwander, K., Merki, Y., Portmann, C., Sigurdardottir, S., Zorbas, A., Engström, C., Gottschalk, J., Amar El Dusouqui, S., Waldvogel-Abramovski, S., Rigal, E., Tissot, J. D., Tinguely, C., Mauvais, S. M., Sarraj, A., Bessero, D., Stalder, M., Infanti, L., Buser, A., Sigle, J., Weingand, T., Castelli, D., Braisch, M. C., Thierbach, J., Heer, S., Schulzki, T., Krawczak, M., Franke, A., & Frey, B. M. (2018). Low-Frequency Blood Group Antigens in Switzerland. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 45(4), 239-250. https://doi.org/10.1159/000490714
Gassner, Christoph, et al. "Low-Frequency Blood Group Antigens in Switzerland." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 45,4 (2018): 239-250. doi: https://doi.org/10.1159/000490714
Gassner C, Degenhardt F, Meyer S, Vollmert C, Trost N, Neuenschwander K, Merki Y, Portmann C, Sigurdardottir S, Zorbas A, Engström C, Gottschalk J, Amar El Dusouqui S, Waldvogel-Abramovski S, Rigal E, Tissot JD, Tinguely C, Mauvais SM, Sarraj A, Bessero D, Stalder M, Infanti L, Buser A, Sigle J, Weingand T, Castelli D, Braisch MC, Thierbach J, Heer S, Schulzki T, Krawczak M, Franke A, Frey BM. Low-Frequency Blood Group Antigens in Switzerland. Transfus Med Hemother. 2018 Jul;45(4):239-250. doi: 10.1159/000490714. Epub 2018 Jul 10. PMID: 30283273; PMCID: PMC6158591.
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Transfus Med Hemother. 2018 Jul;45(4):239-250. doi: 10.1159/000490714. Epub 2018 Jul 10.

Low-Frequency Blood Group Antigens in Switzerland.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Christoph Gassner, Frauke Degenhardt, Stefan Meyer, Caren Vollmert, Nadine Trost, Kathrin Neuenschwander, Yvonne Merki, Claudia Portmann, Sonja Sigurdardottir, Antigoni Zorbas, Charlotte Engström, Jochen Gottschalk, Soraya Amar El Dusouqui, Sophie Waldvogel-Abramovski, Emmanuel Rigal, Jean-Daniel Tissot, Caroline Tinguely, Simon M Mauvais, Amira Sarraj, Daniel Bessero, Michele Stalder, Laura Infanti, Andreas Buser, Jörg Sigle, Tina Weingand, Damiano Castelli, Monica C Braisch, Jutta Thierbach, Sonja Heer, Thomas Schulzki, Michael Krawczak, Andre Franke, Beat M Frey

Affiliations

  1. Blood Transfusion Service Zürich, Swiss Red Cross (SRC), Department of Molecular Diagnostics & Research (MOC), Schlieren, Switzerland.
  2. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  3. Agena Bioscience GmbH, Hamburg, Germany.
  4. Blood Transfusion Service Zürich, SRC, Schlieren, Switzerland.
  5. Blood Transfusion Service Genève, SRC, Geneva, Switzerland.
  6. Blood Transfusion Service Vaud, SRC (recently merged with Interregional Blood Transfusion, SRC, Ltd., Bern), Lausanne, Switzerland.
  7. Interregional Blood Transfusion, SRC, Ltd., Bern, Switzerland.
  8. Blood Transfusion Service Neuchâtel-Jura, SRC, Neuchâtel, Switzerland.
  9. Blood Transfusion Service Valais, SRC (recently merged with Interregional Blood Transfusion, SRC, Ltd., Bern), Sion, Switzerland.
  10. Blood Transfusion Service beider Basel, SRC, Basel, Switzerland.
  11. Blood Transfusion Service Aargau-Solothurn, SRC, Aarau, Switzerland.
  12. Blood Transfusion Service Zentralschweiz, SRC, Luzern, Switzerland.
  13. Blood Transfusion Service Svizzera Italiana, SRC, Lugano, Switzerland.
  14. Blood Transfusion Service Ostschweiz, SRC, St. Gallen, Switzerland.
  15. Blood Transfusion Service Graubünden, SRC, Chur, Switzerland.
  16. Institute for Medical Informatics and Statistics, Christian-Albrechts-University Kiel, Kiel, Germany.

PMID: 30283273 PMCID: PMC6158591 DOI: 10.1159/000490714

Abstract

BACKGROUND: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested.

METHODS: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA).

RESULTS: 326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products.

CONCLUSION: Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.

Keywords: Blood group allele; Blood groups; High-frequency antigen; Low-frequency antigen; Population genetics; Rare donor panel/program; Rare/molecular blood group; Switzerland

References

  1. Transfus Med Hemother. 2015 Jan;42(1):52-8 - PubMed
  2. Expert Rev Mol Diagn. 2015;15(11):1455-64 - PubMed
  3. Transfusion. 2007 Apr;47(4):703-14 - PubMed
  4. Science. 1908 Jul 10;28(706):49-50 - PubMed
  5. Vox Sang. 2016 Apr;110(3):209-18 - PubMed
  6. Vox Sang. 2018 Apr;113(3):290-296 - PubMed
  7. Ann Eugen. 1951 Mar;15(4):323-54 - PubMed
  8. Nat Genet. 2013 May;45(5):537-41 - PubMed
  9. Hum Hered. 2010;70(2):141-9 - PubMed
  10. Blood. 2003 Jan 15;101(2):752-7 - PubMed
  11. Curr Biol. 2008 Aug 26;18(16):1241-8 - PubMed
  12. Blood. 1995 Aug 15;86(4):1590-4 - PubMed
  13. Blood. 1994 Nov 1;84(9):3205-11 - PubMed
  14. ISBT Sci Ser. 2016 Aug;11(2):118-122 - PubMed
  15. Nature. 2008 Nov 6;456(7218):98-101 - PubMed
  16. Am J Psychol. 1987 Fall-Winter;100(3-4):441-71 - PubMed
  17. Immunohematology. 2004;20(4):244-8 - PubMed
  18. Transfus Med Rev. 2013 Jan;27(1):2-9 - PubMed
  19. Vox Sang. 2012 Apr;102(3):234-42 - PubMed
  20. Transfusion. 2014 Dec;54(12):3198-207 - PubMed
  21. J Clin Invest. 1994 Sep;94(3):1050-8 - PubMed
  22. Vox Sang. 2009 Feb;96(2):167-79 - PubMed
  23. Blood. 2001 May 1;97(9):2879-85 - PubMed

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