Display options
Cite
Vanegas YAM, Azzouqa AM, Menke DM, et al. Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases. Hematol Rep. 2018;10(3):7658doi: 10.4081/hr.2018.7658.
Vanegas, Y. A. M., Azzouqa, A. M., Menke, D. M., Foran, J. M., & Vishnu, P. (2018). Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases. Hematology reports, 10(3), 7658. https://doi.org/10.4081/hr.2018.7658
Vanegas, Yenny Alejandra Moreno, et al. "Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases." Hematology reports vol. 10,3 (2018): 7658. doi: https://doi.org/10.4081/hr.2018.7658
Vanegas YAM, Azzouqa AM, Menke DM, Foran JM, Vishnu P. Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases. Hematol Rep. 2018 Sep 05;10(3):7658. doi: 10.4081/hr.2018.7658. eCollection 2018 Sep 05. PMID: 30283621; PMCID: PMC6151345.
Copy Download .nbib Format: NLM
Share it on

Hematol Rep. 2018 Sep 05;10(3):7658. doi: 10.4081/hr.2018.7658. eCollection 2018 Sep 05.

Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases.

Hematology reports

Yenny Alejandra Moreno Vanegas, Abdel-Ghani M Azzouqa, David M Menke, James M Foran, Prakash Vishnu

Affiliations

  1. Divisions of Hematology and Medical Oncology.
  2. Department of Laboratory Medicine and Pathology, Medical Oncology, Mayo Clinic, Jacksonville, FL, USA.

PMID: 30283621 PMCID: PMC6151345 DOI: 10.4081/hr.2018.7658

Abstract

Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.

Keywords: Concurrent; acute myeloid leukemia; acute promyelocytic leukemia; management; myelodysplastic syndrome

References

  1. J Clin Oncol. 2014 Sep 1;32(25):2691-8 - PubMed
  2. Blood. 2010 Mar 4;115(9):1690-6 - PubMed
  3. Stem Cell Investig. 2016 Mar 24;3:8 - PubMed
  4. Blood. 2016 May 19;127(20):2391-405 - PubMed
  5. Ann Pharmacother. 2007 May;41(5):802-11 - PubMed
  6. Ann Lab Med. 2014 Mar;34(2):152-4 - PubMed
  7. Cancer Genet Cytogenet. 2001 Dec;131(2):141-3 - PubMed
  8. Haematologica. 2002 Oct;87(10):1109-11 - PubMed
  9. Eur J Haematol. 2010 Sep;85(3):217-26 - PubMed
  10. Hematol Oncol Stem Cell Ther. 2017 Feb 1;:null - PubMed
  11. Am J Clin Pathol. 2012 Mar;137(3):395-402 - PubMed
  12. J Res Med Sci. 2016 Sep 01;21:78 - PubMed
  13. Blood. 2001 Nov 1;98(9):2862-4 - PubMed
  14. J La State Med Soc. 2017 May-Jun;169(3):68-70 - PubMed
  15. Semin Oncol. 2011 Oct;38(5):658-66 - PubMed
  16. Leuk Res. 2012 Dec;36(12):1490-5 - PubMed

Publication Types