Display options
Cite
IsHak WW, Wen RY, Naghdechi L, et al. Pain and Depression: A Systematic Review. Harv Rev Psychiatry. 2018;26(6):352-363doi: 10.1097/HRP.0000000000000198.
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., Yadegar, J., Hanna, S., Sadek, A., Aguilar-Hernandez, L., Danovitch, I., & Louy, C. (2018). Pain and Depression: A Systematic Review. Harvard review of psychiatry, 26(6), 352-363. https://doi.org/10.1097/HRP.0000000000000198
IsHak, Waguih William, et al. "Pain and Depression: A Systematic Review." Harvard review of psychiatry vol. 26,6 (2018): 352-363. doi: https://doi.org/10.1097/HRP.0000000000000198
IsHak WW, Wen RY, Naghdechi L, Vanle B, Dang J, Knosp M, Dascal J, Marcia L, Gohar Y, Eskander L, Yadegar J, Hanna S, Sadek A, Aguilar-Hernandez L, Danovitch I, Louy C. Pain and Depression: A Systematic Review. Harv Rev Psychiatry. 2018 Nov/Dec;26(6):352-363. doi: 10.1097/HRP.0000000000000198. PMID: 30407234.
Copy Download .nbib Format: NLM
Share it on

Harv Rev Psychiatry. 2018 Nov/Dec;26(6):352-363. doi: 10.1097/HRP.0000000000000198.

Pain and Depression: A Systematic Review.

Harvard review of psychiatry

Waguih William IsHak, Raymond Y Wen, Lancer Naghdechi, Brigitte Vanle, Jonathan Dang, Michelle Knosp, Julieta Dascal, Lobsang Marcia, Yasmine Gohar, Lidia Eskander, Justin Yadegar, Sophia Hanna, Antonious Sadek, Leslie Aguilar-Hernandez, Itai Danovitch, Charles Louy

Affiliations

  1. From the David Geffen School of Medicine at University of California Los Angeles (Drs. IsHak and Sadek; Mr. Marcia); Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Naghdechi, Vanle, Dang, Eskander, Sadek, Danovitch, and Louy; Messrs. Wen, Marcia, Yadegar; Mss. Dascal, Gohar, Aguilar-Hernandez); University of California, Riverside (Mr. Wen and Ms. Gohar); Western University of Health Sciences (Dr. Naghdechi); Harnett Health Systems, Dunn, NC (Dr. Knosp); California State University Long Beach (Ms. Hanna).

PMID: 30407234 DOI: 10.1097/HRP.0000000000000198

Abstract

BACKGROUND: Pain comorbid with depression is frequently encountered in clinical settings and often leads to significant impaired functioning. Given the complexity of comorbidities, it is important to address both pain and depressive symptoms when evaluating treatment options.

AIM: To review studies addressing pain comorbid with depression, and to report the impact of current treatments.

METHOD: A systematic search of the literature databases was conducted according to predefined criteria. Two authors independently conducted a focused analysis of the full-text articles and reached a consensus on 28 articles to be included in this review.

RESULTS: Overall, studies suggested that pain and depression are highly intertwined and may co-exacerbate physical and psychological symptoms. These symptoms could lead to poor physical functional outcomes and longer duration of symptoms. An important biochemical basis for pain and depression focuses on serotonergic and norepinephrine systems, which is evident in the pain-ameliorating properties of serotonergic and norepinephrine antidepressants. Alternative pharmacotherapies such as ketamine and cannabinoids appear to be safe and effective options for improving depressive symptoms and ameliorating pain. In addition, cognitive-behavioral therapy may be a promising tool in the management of chronic pain and depression.

CONCLUSION: The majority of the literature indicates that patients with pain and depression experience reduced physical, mental, and social functioning as opposed to patients with only depression or only pain. In addition, ketamine, psychotropic, and cognitive-behavioral therapies present promising options for treating both pain and depression.

MeSH terms

Publication Types