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Rosenqvist N, Asuni AA, Andersson CR, et al. Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau. Alzheimers Dement (N Y). 2018;4:521-534doi: 10.1016/j.trci.2018.09.005.
Rosenqvist, N., Asuni, A. A., Andersson, C. R., Christensen, S., Daechsel, J. A., Egebjerg, J., Falsig, J., Helboe, L., Jul, P., Kartberg, F., Pedersen, L. �. �., Sigurdsson, E. M., Sotty, F., Skjødt, K., Stavenhagen, J. B., Volbracht, C., & Pedersen, J. T. (2018). Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau. Alzheimer's & dementia (New York, N. Y.), 4521-534. https://doi.org/10.1016/j.trci.2018.09.005
Rosenqvist, Nina, et al. "Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau." Alzheimer's & dementia (New York, N. Y.) vol. 4 (2018): 521-534. doi: https://doi.org/10.1016/j.trci.2018.09.005
Rosenqvist N, Asuni AA, Andersson CR, Christensen S, Daechsel JA, Egebjerg J, Falsig J, Helboe L, Jul P, Kartberg F, Pedersen LØ, Sigurdsson EM, Sotty F, Skjødt K, Stavenhagen JB, Volbracht C, Pedersen JT. Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau. Alzheimers Dement (N Y). 2018 Oct 14;4:521-534. doi: 10.1016/j.trci.2018.09.005. eCollection 2018. PMID: 30386817; PMCID: PMC6205114.
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Alzheimers Dement (N Y). 2018 Oct 14;4:521-534. doi: 10.1016/j.trci.2018.09.005. eCollection 2018.

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau.

Alzheimer's & dementia (New York, N. Y.)

Nina Rosenqvist, Ayodeji A Asuni, Christian R Andersson, Søren Christensen, Justus A Daechsel, Jan Egebjerg, Jeppe Falsig, Lone Helboe, Pia Jul, Fredrik Kartberg, Lars Ø Pedersen, Einar M Sigurdsson, Florence Sotty, Karsten Skjødt, Jeffrey B Stavenhagen, Christiane Volbracht, Jan T Pedersen

Affiliations

  1. H. Lundbeck A/S, Valby, Denmark.
  2. Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA.
  3. Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
  4. Department of Cancer and Inflammarion Research, University of Southern Denmark, Odense C, Denmark.
  5. Therachon AG, Basel, Switzerland.

PMID: 30386817 PMCID: PMC6205114 DOI: 10.1016/j.trci.2018.09.005

Abstract

INTRODUCTION: The abnormal hyperphosphorylation of the microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD) and other tauopathies.

METHODS: Highly specific and selective anti-pS396-tau antibodies have been generated using peptide immunization with screening against pathologic hyperphosphorylated tau from rTg4510 mouse and AD brains and selection in in vitro and in vivo tau seeding assays.

RESULTS: The antibody C10.2 bound specifically to pS396-tau with an IC

DISCUSSION: Targeting pS396-tau with an antibody like C10.2 may provide therapeutic benefit in AD and other tauopathies.

Keywords: Anti-tau antibodies; C10.2; C5.2; C8.3; D1.2; Monoclonal antibody; Phospho-serine 396; Tau seeding

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