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Vojinovic D, Kavousi M, Ghanbari M, et al. Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness. Front Genet. 2018;9:420doi: 10.3389/fgene.2018.00420.
Vojinovic, D., Kavousi, M., Ghanbari, M., Brouwer, R. W. W., van Rooij, J. G. J., van den Hout, M. C. G. N., Kraaij, R., van Ijcken, W. F. J., Uitterlinden, A. G., van Duijn, C. M., & Amin, N. (2018). Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness. Frontiers in genetics, 9420. https://doi.org/10.3389/fgene.2018.00420
Vojinovic, Dina, et al. "Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness." Frontiers in genetics vol. 9 (2018): 420. doi: https://doi.org/10.3389/fgene.2018.00420
Vojinovic D, Kavousi M, Ghanbari M, Brouwer RWW, van Rooij JGJ, van den Hout MCGN, Kraaij R, van Ijcken WFJ, Uitterlinden AG, van Duijn CM, Amin N. Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness. Front Genet. 2018 Oct 09;9:420. doi: 10.3389/fgene.2018.00420. eCollection 2018. PMID: 30356672; PMCID: PMC6189289.
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Front Genet. 2018 Oct 09;9:420. doi: 10.3389/fgene.2018.00420. eCollection 2018.

Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness.

Frontiers in genetics

Dina Vojinovic, Maryam Kavousi, Mohsen Ghanbari, Rutger W W Brouwer, Jeroen G J van Rooij, Mirjam C G N van den Hout, Robert Kraaij, Wilfred F J van Ijcken, Andre G Uitterlinden, Cornelia M van Duijn, Najaf Amin

Affiliations

  1. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  2. Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Department of Cell Biology, Center for Biomics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  4. Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  5. Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

PMID: 30356672 PMCID: PMC6189289 DOI: 10.3389/fgene.2018.00420

Abstract

Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of individuals in the extremes of cIMT trait distribution (>90th percentile) in a large family-based study from a genetically isolated population in the Netherlands. Linked regions were subsequently explored by fine-mapping using exome sequencing. We observed significant evidence of linkage on chromosomes 2p16.3 [rs1017418, heterogeneity LOD (HLOD) = 3.35], 19q13.43 (rs3499, HLOD = 9.09), 20p13 (rs1434789, HLOD = 4.10), and 21q22.12 (rs2834949, HLOD = 3.59). Fine-mapping using exome sequencing data identified a non-coding variant (rs62165235) in

Keywords: atherosclerosis; exome sequencing; genetics; intima-media thickness; linkage

References

  1. FASEB J. 2002 Sep;16(11):1423-5 - PubMed
  2. Circ Cardiovasc Genet. 2016 Dec;9(6):511-520 - PubMed
  3. Atherosclerosis. 2010 Jul;211(1):224-30 - PubMed
  4. EMBO Mol Med. 2010 Mar;2(3):79-89 - PubMed
  5. Gene. 2003 Oct 16;316:143-56 - PubMed
  6. Circ Res. 2005 Apr 1;96(6):667-74 - PubMed
  7. PLoS Med. 2017 Sep 12;14(9):e1002383 - PubMed
  8. Nat Genet. 2011 Sep 25;43(11):1098-103 - PubMed
  9. Cell Metab. 2010 Aug 4;12(2):142-53 - PubMed
  10. Circ Cardiovasc Genet. 2014 Jun;7(3):359-64 - PubMed
  11. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2763-8 - PubMed
  12. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):E61; author reply E62 - PubMed
  13. Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 - PubMed
  14. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16636-41 - PubMed
  15. Bioinformatics. 2016 May 1;32(9):1423-6 - PubMed
  16. Eur J Hum Genet. 2008 Jul;16(7):854-60 - PubMed
  17. N Engl J Med. 2011 Jul 21;365(3):213-21 - PubMed
  18. Clin Cardiol. 2009 Dec;32(12):705-10 - PubMed
  19. Stroke. 2005 Nov;36(11):2351-6 - PubMed
  20. BMC Proc. 2011 Nov 29;5 Suppl 9:S105 - PubMed
  21. PLoS One. 2013 Jul 04;8(7):e67768 - PubMed
  22. Nucleic Acids Res. 1988 Feb 11;16(3):1215 - PubMed
  23. Source Code Biol Med. 2014 Dec 05;9(1):26 - PubMed
  24. Hum Reprod Update. 2012 Mar-Apr;18(2):112-26 - PubMed
  25. Diabetes. 2012 Feb;61(2):463-73 - PubMed
  26. An Sist Sanit Navar. 2004 Sep-Dec;27(3):335-44 - PubMed
  27. Atherosclerosis. 2009 Dec;207(2):399-404 - PubMed
  28. Atherosclerosis. 2015 Sep;242(1):334-9 - PubMed
  29. Ann Hum Genet. 2005 May;69(Pt 3):288-95 - PubMed
  30. Stroke. 2005 Mar;36(3):540-5 - PubMed
  31. Biochim Biophys Acta. 2013 Jun;1832(6):718-28 - PubMed
  32. Trends Cardiovasc Med. 2014 Jan;24(1):45-51 - PubMed
  33. Mol Psychiatry. 2017 Apr;22(4):537-543 - PubMed
  34. Am J Hum Genet. 2004 Feb;74(2):253-61 - PubMed
  35. Stroke. 2003 Feb;34(2):397-401 - PubMed
  36. Mol Psychiatry. 2012 Oct;17(10):1031-41 - PubMed
  37. Heredity (Edinb). 2005 Sep;95(3):221-7 - PubMed
  38. Stroke. 2009 Jul;40(7):2307-12 - PubMed
  39. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1256-61 - PubMed
  40. Epigenomics. 2016 Mar;8(3):359-71 - PubMed
  41. Mol Psychiatry. 2018 May;23(5):1120-1126 - PubMed
  42. PLoS One. 2009 Oct 21;4(10):e7540 - PubMed
  43. Nat Rev Genet. 2015 May;16(5):275-84 - PubMed
  44. Nat Genet. 2011 Sep 11;43(10):940-7 - PubMed
  45. JAMA. 2012 Aug 22;308(8):796-803 - PubMed
  46. PLoS Genet. 2010 Dec 09;6(12):e1001239 - PubMed
  47. J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C7-12 - PubMed
  48. Nat Genet. 2002 Jan;30(1):97-101 - PubMed
  49. Circulation. 2007 Jan 30;115(4):459-67 - PubMed
  50. J Clin Endocrinol Metab. 2013 Jan;98(1):E185-90 - PubMed
  51. Nat Genet. 2012 Dec;44(12):1326-9 - PubMed
  52. Eur J Hum Genet. 2004 Jul;12(7):527-34 - PubMed
  53. Cardiovasc Res. 2011 Jan 1;89(1):184-92 - PubMed
  54. Genome Res. 2012 Sep;22(9):1790-7 - PubMed
  55. Nat Genet. 2014 Mar;46(3):310-5 - PubMed
  56. Circ Res. 2001 Apr 27;88(8):747-9 - PubMed
  57. Biol Psychiatry. 2017 Apr 15;81(8):702-707 - PubMed
  58. Trends Genet. 2012 Jun;28(6):267-75 - PubMed
  59. Eur Respir Rev. 2017 Feb 21;26(143): - PubMed
  60. Sci Rep. 2015 Aug 19;5:13461 - PubMed
  61. Natl Vital Stat Rep. 2016 Feb 16;64(2):1-119 - PubMed
  62. EMBO Mol Med. 2013 Dec;5(12):1901-17 - PubMed
  63. Nat Genet. 2017 Oct;49(10):1458-1467 - PubMed
  64. Cardiovasc Res. 2015 Jan 1;105(1):65-74 - PubMed
  65. Endocrinology. 2011 Dec;152(12):4915-26 - PubMed
  66. Genome Med. 2015 Feb 23;7(1):16 - PubMed
  67. Atherosclerosis. 2013 Nov;231(1):120-3 - PubMed

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