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Front Physiol. 2018 Sep 25;9:1346. doi: 10.3389/fphys.2018.01346. eCollection 2018.

Fat and Lean Mass Predict Bone Mass During Energy Restriction in Sedentary and Exercising Rodents.

Frontiers in physiology

Corinne E Metzger, Sibyl N Swift, Kyunghwa Baek, Mary Jane De Souza, Susan A Bloomfield

Affiliations

  1. Department of Health and Kinesiology, Texas A&M University, College Station, TX, United States.
  2. Department of Kinesiology, Pennsylvania State University, State College, PA, United States.
  3. Department of Physiology, Pennsylvania State University, State College, PA, United States.

PMID: 30356821 PMCID: PMC6190840 DOI: 10.3389/fphys.2018.01346

Abstract

Energy restriction (ER) causes bone loss, but the impact of exercise during ER is less understood. In this study, we examined the impact of metabolic hormones and body composition on both total body bone mineral content (BMC) and local (proximal tibia) volumetric bone mineral density (vBMD) during short- (4 weeks) and long-term (12 weeks) ER with and without exercise in adult female rats. Our first goal was to balance energy between sedentary and exercising groups to determine the impact of exercise during ER. Second, we aimed to determine the strongest predictors of bone outcomes during ER with energy-matched exercising groups.

Keywords: bone mineral content; energy restriction; fat mass; lean mass; treadmill running

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