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Angew Chem Int Ed Engl. 2018 Dec 03;57(49):16171-16175. doi: 10.1002/anie.201809398. Epub 2018 Nov 11.

2,6-Dimercuriphenol as a Bifacial Dinuclear Organometallic Nucleobase.

Angewandte Chemie (International ed. in English)

Dattatraya Uttam Ukale, Tuomas Lönnberg

Affiliations

  1. Department of Chemistry, University of Turku, Vatselankatu 2, 20014, Turku, Finland.

PMID: 30358071 DOI: 10.1002/anie.201809398

Abstract

A C-nucleoside having 2,6-dimercuriphenol as the base moiety has been synthesized and incorporated into an oligonucleotide. NMR and UV melting experiments revealed the ability of this bifacial organometallic nucleobase surrogate to form stable dinuclear Hg

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: base triple; hybridization; mercury; nucleobases; oligonucleotides

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