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Horie S, Gonzalez HE, Laffey JG, et al. Cell therapy in acute respiratory distress syndrome. J Thorac Dis. 2018;10(9):5607-5620doi: 10.21037/jtd.2018.08.28.
Horie, S., Gonzalez, H. E., Laffey, J. G., & Masterson, C. H. (2018). Cell therapy in acute respiratory distress syndrome. Journal of thoracic disease, 10(9), 5607-5620. https://doi.org/10.21037/jtd.2018.08.28
Horie, Shahd, et al. "Cell therapy in acute respiratory distress syndrome." Journal of thoracic disease vol. 10,9 (2018): 5607-5620. doi: https://doi.org/10.21037/jtd.2018.08.28
Horie S, Gonzalez HE, Laffey JG, Masterson CH. Cell therapy in acute respiratory distress syndrome. J Thorac Dis. 2018 Sep;10(9):5607-5620. doi: 10.21037/jtd.2018.08.28. PMID: 30416812; PMCID: PMC6196176.
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J Thorac Dis. 2018 Sep;10(9):5607-5620. doi: 10.21037/jtd.2018.08.28.

Cell therapy in acute respiratory distress syndrome.

Journal of thoracic disease

Shahd Horie, Hector Esteban Gonzalez, John G Laffey, Claire H Masterson

Affiliations

  1. Regenerative Medicine Institute (REMEDI), CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland.
  2. Department of Anesthesia and Intensive Care Medicine, Galway University Hospitals, SAOLTA Hospital Group, Ireland.

PMID: 30416812 PMCID: PMC6196176 DOI: 10.21037/jtd.2018.08.28

Abstract

Acute respiratory distress syndrome (ARDS) is driven by a severe pro-inflammatory response resulting in lung damage, impaired gas exchange and severe respiratory failure. There is no specific treatment that effectively improves outcome in ARDS. However, in recent years, cell therapy has shown great promise in preclinical ARDS studies. A wide range of cells have been identified as potential candidates for use, among these are mesenchymal stromal cells (MSCs), which are adult multi-lineage cells that can modulate the immune response and enhance repair of damaged tissue. The therapeutic potential of MSC therapy for sepsis and ARDS has been demonstrated in multiple

Keywords: Acute respiratory distress syndrome (ARDS); cell therapy; mesenchymal stromal cells (MSCs)

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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