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Rahimi M, Ghoreshi M, Emami B, et al. Preventive Effect of Hydroalcoholic Extract of . Int J Prev Med. 2018;9:92doi: 10.4103/ijpvm.IJPVM_312_17.
Rahimi, M., Ghoreshi, M., Emami, B., Shafei, M. N., Hosseini, M., & Khajavirad, A. (2018). Preventive Effect of Hydroalcoholic Extract of . International journal of preventive medicine, 992. https://doi.org/10.4103/ijpvm.IJPVM_312_17
Rahimi, Maryam, et al. "Preventive Effect of Hydroalcoholic Extract of ." International journal of preventive medicine vol. 9 (2018): 92. doi: https://doi.org/10.4103/ijpvm.IJPVM_312_17
Rahimi M, Ghoreshi M, Emami B, Shafei MN, Hosseini M, Khajavirad A. Preventive Effect of Hydroalcoholic Extract of . Int J Prev Med. 2018 Oct 12;9:92. doi: 10.4103/ijpvm.IJPVM_312_17. eCollection 2018. PMID: 30450175; PMCID: PMC6202776.
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Int J Prev Med. 2018 Oct 12;9:92. doi: 10.4103/ijpvm.IJPVM_312_17. eCollection 2018.

Preventive Effect of Hydroalcoholic Extract of .

International journal of preventive medicine

Maryam Rahimi, Mina Ghoreshi, Bahman Emami, Mohammad Naser Shafei, Mahmoud Hosseini, Abolfazl Khajavirad

Affiliations

  1. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad, University of Medical Sciences, Mashhad, Iran.

PMID: 30450175 PMCID: PMC6202776 DOI: 10.4103/ijpvm.IJPVM_312_17

Abstract

METHODS: After anesthesia, femoral artery and vein of rats were cannulated for recording cardiovascular responses and drug injection, respectively. Systolic blood pressure (SBP), mean arterial blood pressure (MAP), and heart rate (HR) were recorded continuously by power lab software. Rats were divided into saline, AngII (50 ng/kg), AngII + Losartan (10 mg/kg), and three groups of R.D extract (250, 500, and 1000 mg/kg). Losartan and AngII were administered intravenously and the other ones intraperitoneal. In the R.D groups, 30 min after injection of the extract, AngII was injected and the maximum changes in SBP, MAP, and HR were calculated and compared to that in control and AngII groups.

RESULTS: Results show that AngII significantly increased SBP, MAP, and decreased HR than the control group which was blocked by losartan. SBP and MAP in R.D + AngII groups were significantly lower than AngII alone (

CONCLUSIONS: The preventive effect of hydroalcoholic extract of R.D on cardiovascular parameters maybe is mediated by suppression of AngII activity.

Keywords: Angiotensin II; Rosa damascena; blood pressure; heart rate; rennin–angiotensin system

Conflict of interest statement

There are no conflicts of interest

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