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Chiappini E, Bianconi M, Dalzini A, et al. Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms. Aging (Albany NY). 2018;10(11):3610-3625doi: 10.18632/aging.101622.
Chiappini, E., Bianconi, M., Dalzini, A., Petrara, M. R., Galli, L., Giaquinto, C., & De Rossi, A. (2018). Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms. Aging, 10(11), 3610-3625. https://doi.org/10.18632/aging.101622
Chiappini, Elena, et al. "Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms." Aging vol. 10,11 (2018): 3610-3625. doi: https://doi.org/10.18632/aging.101622
Chiappini E, Bianconi M, Dalzini A, Petrara MR, Galli L, Giaquinto C, De Rossi A. Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms. Aging (Albany NY). 2018 Nov 11;10(11):3610-3625. doi: 10.18632/aging.101622. PMID: 30418933; PMCID: PMC6286860.
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Aging (Albany NY). 2018 Nov 11;10(11):3610-3625. doi: 10.18632/aging.101622.

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms.

Aging

Elena Chiappini, Martina Bianconi, Annalisa Dalzini, Maria Raffaella Petrara, Luisa Galli, Carlo Giaquinto, Anita De Rossi

Affiliations

  1. Infectious Disease Unit, Meyer Children's Hospital, Department of Science Health, University of Florence, Florence, Italy.
  2. Section of Oncology and Immunology, Department of Surgery, Oncology and Gastroenterology, Unit of viral Oncology and AIDS Reference Center, University of Padova, Padova, Italy.
  3. Department of Mother and Child Health, University of Padova, Padova, Italy.
  4. Istituto Oncologico Veneto IOV-IRCCS, Padova, Italy.

PMID: 30418933 PMCID: PMC6286860 DOI: 10.18632/aging.101622

Abstract

BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children.

METHODS: A narrative review was performed searching studies on PubMed published in English language in 2004-2017, using appropriate key words, including "aging", "children", "HIV", "AIDS", "immunosenescence", "pathogenesis", "clinical conditions".

RESULTS: Premature immunosenescence phenotype of B and T cells in HIV-infected children is mediated through immune system activation and chronic inflammation. Ongoing inflammation processes have been documented by increased levels of pathogen-associated molecular patterns (PAMPS), increased mitochondrial damage, higher levels of pro-inflammatory cytokines, and a positive correlation between sCD14 levels and percentages of activated CD8

CONCLUSION: Aging processes in children with HIV infection impact their quality and length of life. Further studies regarding the mechanisms involved in premature aging are needed to search for potential targets of treatment.

Keywords: HIV; aging; antiretroviral therapy; children; telomeres

References

  1. J Int AIDS Soc. 2015 Dec 02;18(Suppl 6):20258 - PubMed
  2. BMJ. 2009 Jan 26;338:a3172 - PubMed
  3. AIDS. 2009 Sep 10;23(14):1893-901 - PubMed
  4. Nature. 2008 Oct 2;455(7213):633-7 - PubMed
  5. Nat Med. 2006 Dec;12(12):1365-71 - PubMed
  6. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9 - PubMed
  7. Cell Death Dis. 2015 May 28;6:e1774 - PubMed
  8. Cancer Immunol Immunother. 2004 Oct;53(10):925-33 - PubMed
  9. AIDS. 2013 Jan 28;27(3):469-74 - PubMed
  10. AIDS. 2013 Jun 1;27(9):1513-6 - PubMed
  11. J Pediatr Hematol Oncol. 2014 Mar;36(2):111-7 - PubMed
  12. Clin Interv Aging. 2010 Sep 23;5:285-92 - PubMed
  13. Nucleic Acids Res. 2007;35(21):7140-9 - PubMed
  14. Mol Cell. 2001 Jun;7(6):1201-11 - PubMed
  15. PLoS One. 2016 Apr 20;11(4):e0153837 - PubMed
  16. Nat Rev Immunol. 2012 Sep;12(9):636-48 - PubMed
  17. Clin Infect Dis. 2015 Sep 15;61(6):988-95 - PubMed
  18. PLoS One. 2012;7(11):e47505 - PubMed
  19. J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):447-54 - PubMed
  20. PLoS One. 2015 Mar 25;10(3):e0119201 - PubMed
  21. PLoS One. 2011 Jan 26;6(1):e16459 - PubMed
  22. Cell. 2014 Nov 6;159(4):709-13 - PubMed
  23. AIDS. 2017 Jun 1;31 Suppl 2:S105-S119 - PubMed
  24. Handb Clin Neurol. 2018;152:99-116 - PubMed
  25. J Immunol. 2009 Oct 1;183(7):4329-36 - PubMed
  26. PLoS One. 2013 May 15;8(5):e64398 - PubMed
  27. Int J Infect Dis. 2016 Dec;53:61-68 - PubMed
  28. Semin Nephrol. 2008 Nov;28(6):585-94 - PubMed
  29. J Int AIDS Soc. 2017 Jun 28;20(1):21952 - PubMed
  30. AIDS. 2004 Apr 9;18(6):960-3 - PubMed
  31. Semin Cancer Biol. 2011 Dec;21(6):354-9 - PubMed
  32. J Med Virol. 2007 May;79(5):639-46 - PubMed
  33. Pediatr Infect Dis J. 2011 Sep;30(9):764-8 - PubMed
  34. Nat Rev Immunol. 2009 Apr;9(4):235-45 - PubMed
  35. Pediatr Infect Dis J. 2014 Aug;33(8):e207-12 - PubMed
  36. J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):831 - PubMed
  37. Clin Infect Dis. 2015 Apr 1;60(7):1111-9 - PubMed
  38. Endocrinol Metab Clin North Am. 2014 Sep;43(3):807-28 - PubMed
  39. AIDS Res Hum Retroviruses. 2006 May;22(5):425-9 - PubMed
  40. J Pediatr. 1998 May;132(5):808-12 - PubMed
  41. Br J Cancer. 2010 Jul 27;103(3):416-22 - PubMed
  42. Proteomics Clin Appl. 2015 Jun;9(5-6):490-500 - PubMed
  43. Annu Rev Immunol. 2002;20:197-216 - PubMed
  44. Curr Opin Cell Biol. 2018 Jun;52:1-7 - PubMed
  45. Atherosclerosis. 2010 Aug;211(2):492-8 - PubMed
  46. Blood. 1999 May 1;93(9):2824-30 - PubMed
  47. Mol Cell. 2016 Apr 21;62(2):157-168 - PubMed
  48. Drugs. 2012 Nov 12;72(16):2051-62 - PubMed
  49. Dev Med Child Neurol. 2016 May;58(5):452-60 - PubMed
  50. J Allergy Clin Immunol. 2014 Feb;133(2):592-4 - PubMed
  51. J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):42-9 - PubMed
  52. J Clin Invest. 1996 Jan 15;97(2):323-30 - PubMed
  53. J Clin Oncol. 2007 Jan 1;25(1):97-101 - PubMed
  54. Pediatr Infect Dis J. 2015 May;34(5 Suppl 1):S14-30 - PubMed
  55. J Int AIDS Soc. 2013 Jun 18;16:18575 - PubMed
  56. Cancer Lett. 2014 May 28;347(1):38-45 - PubMed
  57. Aging Cell. 2015 Aug;14(4):534-46 - PubMed
  58. J Int AIDS Soc. 2013 Jun 18;16:18596 - PubMed
  59. J Infect Dis. 2001 Feb 1;183(3):417-24 - PubMed
  60. Pediatr Infect Dis J. 2017 Jun;36(6):578-583 - PubMed
  61. Pediatr Infect Dis J. 2017 Jan;36(1):63-65 - PubMed
  62. J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):63-8 - PubMed
  63. HIV Med. 2016 Mar;17(3):196-205 - PubMed
  64. Clin Immunol. 2009 Mar;130(3):280-9 - PubMed
  65. J Clin Invest. 2013 Mar;123(3):966-72 - PubMed
  66. Curr HIV/AIDS Rep. 2014 Sep;11(3):233-40 - PubMed
  67. Curr Opin HIV AIDS. 2016 May;11(3):294-300 - PubMed
  68. J Bone Miner Res. 2016 Nov;31(11):1988-1996 - PubMed
  69. Aging (Albany NY). 2017 Apr;9(4):1307-1325 - PubMed
  70. Front Microbiol. 2013 Oct 18;4:311 - PubMed
  71. Braz J Infect Dis. 2015 Nov-Dec;19(6):623-30 - PubMed
  72. PLoS One. 2012;7(7):e39266 - PubMed
  73. J Am Soc Nephrol. 2017 Mar;28(3):862-875 - PubMed
  74. J Med Virol. 2008 Sep;80(9):1507-14 - PubMed
  75. Atherosclerosis. 2008 Feb;196(2):720-6 - PubMed
  76. PLoS Med. 2018 Jan 30;15(1):e1002491 - PubMed
  77. Ageing Res Rev. 2011 Apr;10(2):297-303 - PubMed
  78. J Exp Med. 2008 Aug 4;205(8):1797-805 - PubMed
  79. J Infect Dis. 2011 Feb 15;203(4):452-63 - PubMed
  80. Carcinogenesis. 2010 Jan;31(1):9-18 - PubMed
  81. Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):148-54 - PubMed
  82. Annu Rev Med. 2010;61:169-85 - PubMed
  83. J Immunol. 2005 Apr 15;174(8):4870-9 - PubMed
  84. Pediatr Infect Dis J. 2013 May;32(5):501-8 - PubMed
  85. Pediatr Infect Dis J. 2016 Feb;35(2):196-200 - PubMed
  86. Clin Infect Dis. 2007 Oct 1;45(7):918-24 - PubMed
  87. J Ultrasound Med. 2013 May;32(5):763-8 - PubMed
  88. AIDS. 2016 Jun 1;30(9):1363-73 - PubMed
  89. Nature. 2002 Jul 11;418(6894):191-5 - PubMed
  90. J Allergy Clin Immunol. 2001 Sep;108(3):439-45 - PubMed
  91. AIDS. 2017 Jun 1;31 Suppl 2:S129-S135 - PubMed
  92. J Immunol. 2007 Jun 15;178(12):8212-20 - PubMed
  93. Annu Rev Immunol. 2004;22:745-63 - PubMed
  94. Eur J Prev Cardiol. 2015 Nov;22(11):1452-61 - PubMed
  95. Blood. 2003 Apr 1;101(7):2711-20 - PubMed
  96. J Acquir Immune Defic Syndr. 2010 Jan;53(1):86-94 - PubMed
  97. Curr HIV/AIDS Rep. 2010 Feb;7(1):4-10 - PubMed
  98. J AIDS Clin Res. 2014 Jun;5(6): - PubMed
  99. Nature. 2010 Mar 4;464(7285):104-7 - PubMed

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