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Minotti L, Agnoletto C, Baldassari F, et al. SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?. High Throughput. 2018;7(4)doi: 10.3390/ht7040034.
Minotti, L., Agnoletto, C., Baldassari, F., Corrà, F., & Volinia, S. (2018). SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?. High-throughput, 7(4), . https://doi.org/10.3390/ht7040034
Minotti, Linda, et al. "SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?." High-throughput vol. 7,4 (2018). doi: https://doi.org/10.3390/ht7040034
Minotti L, Agnoletto C, Baldassari F, Corrà F, Volinia S. SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?. High Throughput. 2018 Nov 16;7(4). doi: 10.3390/ht7040034. PMID: 30453571; PMCID: PMC6306726.
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High Throughput. 2018 Nov 16;7(4). doi: 10.3390/ht7040034.

SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?.

High-throughput

Linda Minotti, Chiara Agnoletto, Federica Baldassari, Fabio Corrà, Stefano Volinia

Affiliations

  1. LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy. [email protected].
  2. LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy. [email protected].
  3. LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy. [email protected].
  4. LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy. [email protected].
  5. LTTA, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Fossato di Mortara 70, 44123 Ferrara, Italy. [email protected].

PMID: 30453571 PMCID: PMC6306726 DOI: 10.3390/ht7040034

Abstract

In the last decade, it has been demonstrated that long non-coding RNAs (lncRNAs) are involved in cancer development. The great majority of studies on lncRNAs report alterations, principally on their expression profiles, in several tumor types with respect to the normal tissues of origin. Conversely, since lncRNAs constitute a relatively novel class of RNAs compared to protein-coding transcripts (mRNAs), the landscape of their mutations and variations has not yet been extensively studied. However, in recent years an ever-increasing number of articles have described mutations of lncRNAs. Single-nucleotide polymorphisms (SNPs) that occur within the lncRNA transcripts can affect the structure and function of these RNA molecules, while the presence of a SNP in the promoter region of a lncRNA could alter its expression level. Also, somatic mutations that occur within lncRNAs have been shown to exert important effects in cancer and preliminary data are promising. Overall, the evidence suggests that SNPs and somatic mutation on lncRNAs may play a role in the pathogenesis of cancer, and indicates strong potential for further development of lncRNAs as biomarkers.

Keywords: SNPs; cancer risk; lncRNAs; somatic mutation

Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the de

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