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Chai Y, Coloigner J, Qu X, et al. Tract specific analysis in patients with sickle cell disease. Proc SPIE Int Soc Opt Eng. 2015;9681doi: 10.1117/12.2213617.
Chai, Y., Coloigner, J., Qu, X., Choi, S., Bush, A., Borzage, M., Vu, C., Lepore, N., & Wood, J. (2015). Tract specific analysis in patients with sickle cell disease. Proceedings of SPIE--the International Society for Optical Engineering, 9681. https://doi.org/10.1117/12.2213617
Chai, Yaqiong, et al. "Tract specific analysis in patients with sickle cell disease." Proceedings of SPIE--the International Society for Optical Engineering vol. 9681 (2015). doi: https://doi.org/10.1117/12.2213617
Chai Y, Coloigner J, Qu X, Choi S, Bush A, Borzage M, Vu C, Lepore N, Wood J. Tract specific analysis in patients with sickle cell disease. Proc SPIE Int Soc Opt Eng. 2015 Nov;9681. doi: 10.1117/12.2213617. Epub 2015 Dec 22. PMID: 30344363; PMCID: PMC6192019.
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Proc SPIE Int Soc Opt Eng. 2015 Nov;9681. doi: 10.1117/12.2213617. Epub 2015 Dec 22.

Tract specific analysis in patients with sickle cell disease.

Proceedings of SPIE--the International Society for Optical Engineering

Yaqiong Chai, Julie Coloigner, Xiaoping Qu, Soyoung Choi, Adam Bush, Matt Borzage, Chau Vu, Natasha Lepore, John Wood

Affiliations

  1. CIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
  2. Division of Cardiology, Children's Hospital Los Angeles, CA, USA.
  3. Department of Biomedical Engineering, University of Southern California, CA, USA.
  4. Department of Neonatology, Children's Hospital Los Angeles, CA, USA.
  5. Department of Radiology, University of Southern California, CA, USA.

PMID: 30344363 PMCID: PMC6192019 DOI: 10.1117/12.2213617

Abstract

Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. It affects numerous people in the world and leads to a shorter life span, pain, anemia, serious infections and neurocognitive decline. Tract-Specific Analysis (TSA) is a statistical method to evaluate white matter alterations due to neurocognitive diseases, using diffusion tensor magnetic resonance images. Here, for the first time, TSA is used to compare 11 major brain white matter (WM) tracts between SCD patients and age-matched healthy subjects. Alterations are found in the corpus callosum (CC), the cortico-spinal tract (CST), inferior fronto-occipital fasciculus (IFO), inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF), and uncinated fasciculus (UNC). Based on previous studies on the neurocognitive functions of these tracts, the significant areas found in this paper might be related to several cognitive impairments and depression, both of which are observed in SCD patients.

Keywords: sickle cell disease; statistical analysis; white matter

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