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Wang DN, Wang L, Huang Y, et al. Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Exp Ther Med. 2018;16(5):4114-4118doi: 10.3892/etm.2018.6695.
Wang, D. N., Wang, L., Huang, Y., Hua, L., Cui, H. M., Chen, P. F., Liang, X., Zhang, J. Y., & Liao, D. N. (2018). Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Experimental and therapeutic medicine, 16(5), 4114-4118. https://doi.org/10.3892/etm.2018.6695
Wang, Dan-Ning, et al. "Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart." Experimental and therapeutic medicine vol. 16,5 (2018): 4114-4118. doi: https://doi.org/10.3892/etm.2018.6695
Wang DN, Wang L, Huang Y, Hua L, Cui HM, Chen PF, Liang X, Zhang JY, Liao DN. Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart. Exp Ther Med. 2018 Nov;16(5):4114-4118. doi: 10.3892/etm.2018.6695. Epub 2018 Sep 04. PMID: 30344687; PMCID: PMC6176129.
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Exp Ther Med. 2018 Nov;16(5):4114-4118. doi: 10.3892/etm.2018.6695. Epub 2018 Sep 04.

Effects of early intravenous low-dose of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction heart.

Experimental and therapeutic medicine

Dan-Ning Wang, Lei Wang, Ying Huang, Li Hua, Hai-Ming Cui, Peng-Fei Chen, Xin Liang, Jia-You Zhang, De-Ning Liao

Affiliations

  1. Department of Cardiology, Shanghai Changzheng Hospital, Shanghai 200433, P.R. China.
  2. Department of Cardiology, The 309th Hospital of Chinese People's Liberation Army, Beijing 100193, P.R. China.

PMID: 30344687 PMCID: PMC6176129 DOI: 10.3892/etm.2018.6695

Abstract

This study observed the effects of early intravenous low-doses of metoprolol on cardiac sympathetic activities and electrophysiological properties in myocardial infarction (MI) dogs. Thirty two mongrel dogs with the first diagonal branch of the left anterior descending coronary artery ligated were randomly divided into three groups: The low-dose group was given metoprolol 0.6 mg/kg immediately by intravenous injection (n=12); the target-dose group was given metoprolol 1.6 mg/kg (n=12), and the control group was injected with normal saline at the same dose of the target-dose group (n=8). Norepinephrine (NE) and epinephrine (E) levels in the coronary sinus (CS) blood as well as the ventricular effective refractory period (ERP) were all measured during the experiments. We found that NE and E concentrations in the three groups were all increased compared with the previous measurement before ligation. ERP values after MI were significantly decreased in all three groups compared with the first measurements. The three groups all exhibited uneven shortness of ERP among different regions, with significant shortness in infarcted area. Furthermore, there was no difference between the low and target-dose of metoprolol in the reduction of regional ERP, and the same effect was also observed in induced arrhythmias. In conclusion, a lower dose of metoprolol performed similarly as target-dose in reducing the catecholamine concentrations in dogs with MI. Our study demonstrated that a lower dose of metoprolol may be reasonable compared with the target-dose in β-blocker therapy due to similar effect and lower toxicity.

Keywords: effective refractory period; metoprolol; myocardial infarction; β-blocker

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